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An arginine-to-histidine replacement at residue 435 in the binding domain of IgG3 to FcRn increases the transplacental transfer and half-life of malaria-specific IgG3 in young infants and is associated with reduced risk of clinical malaria during infancy.
these findings establish a novel mechanism of humoral protection in the eye involving FcRn and may facilitate vaccine and therapeutic development for other ocular surface diseases
Data suggest that, unlike albumin (zeige ALB ELISA Kits) with low FcRn-binding affinity, albumin (zeige ALB ELISA Kits) with high FcRn-binding affinity (due to genetic variation/genetic engineering) is directed less to lysosomes and more to endosomes, suggestive of FcRn-directed albumin (zeige ALB ELISA Kits) salvage from lysosomal degradation. (FcRn = neonatal Fc receptor)
the localization of FcRn alpha-chain in fixed nasal tissue, was studied.
FcRn is involved in transport of aflibercept through REC (zeige ZDHHC2 ELISA Kits) in vitro.
this study shows that FcRn may be associated with the transport and metabolism of IgG in thyrocytes and that transport is independent of IgG type, and that FcRn may be involved in Hashimoto's thyroiditis pathogenesis
This review summarizes the main findings on Fc Receptor neonatal biology, function and distribution throughout different tissues.
The results suggest that regardless of hyperglycemia degree, it decreases FcRn expression in placenta and blood cells and compromises the production and transfer of antibodies from maternal blood to newborns.
Data indicate improved pharmacokinetics through enhanced neonatal Fc receptor (FcRn) interactions were apparent for a complementarity-determining region (CDR (zeige RUNX1T1 ELISA Kits)) charge-patch normalized monoclonal antibody (mAb) which was affected by non-specific clearance.
analysis of binding motifs in the hFCGRT promoter that interact with their corresponding (Sp1 (zeige PSG1 ELISA Kits), Sp2, Sp3 (zeige SP3 ELISA Kits), c-Fos, c-Jun (zeige JUN ELISA Kits), YY1 (zeige YY1 ELISA Kits), and C/EBPbeta (zeige CEBPB ELISA Kits) or C/EBPdelta (zeige CEBPD ELISA Kits)) transcription factors (TFs) suggests their involvement in regulation of human FCGRT gene expression
The transport of IgGs in the mammary gland, by FcRn, was investigated.
The present data support the notion that FcRn might be involved in the transfer of maternal immunoglobulins and in the local defense mechanism of the mammary gland.
FcRn alpha chain gene has acquired several repetitive sequences in its 5'-flanking region, including multiple SINE and LINE elements. Potential binding sites for transcription factors within the 5'-flanking sequence were identified
haplotype could also weaken the IgG-FcRn affinity, which may increase the IgG concentration in the milk.
Preproinsulin (zeige INS ELISA Kits) fused to Fc administered to pregnant mice efficiently accumulated in fetuses through the placental neonatal Fc receptor and protected them from subsequent diabetes development.
The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
Characterization and screening of IgG binding to the neonatal Fc receptor.
Fc receptor promotes formation of subepithelial immune complexes and subsequent glomerular pathology leading to proteinuria
Abundant intracellular IgG in enterocytes and endoderm lacking FcRn.
Extending serum half-life of albumin (zeige ALB ELISA Kits) by engineering neonatal Fc receptor (FcRn) binding.
FcRn thus has a primary role within mucosal tissues in activating local immune responses that are critical for priming efficient anti-tumor immunosurveillance
Neonatal Fc receptor for IgG uptake mediates intestinal absorption of IgG(1) anti-IgE/IgE immune complexes.
Nck and Cdc42 co-operate to recruit N-WASP to promote FcgammaR-mediated phagocytosis.
AMG (zeige AMELX ELISA Kits) 386 clearance in FcRn-knockout mice was 18-fold faster at the 3-mg/kg dose.
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
FcRn alpha chain
, IgG Fc fragment receptor transporter alpha chain
, IgG receptor FcRn large subunit p51
, immunoglobulin receptor, intestinal, heavy chain
, major histocompatibility complex class I-like Fc receptor
, neonatal Fc receptor
, neonatal Fc-receptor for Ig
, IgG transcytosis and recycling receptor
, MHC class I-related Fc gamma receptor
, igG receptor FcRn large subunit p51
, neonatal Fc receptor FcRn
, Fc receptor
, Fc fragment immunoglobulin G receptor
, Fc receptor, IgG, alpha chain transporter
, igG Fc fragment receptor transporter alpha chain