anti-Human CD24 Antikörper für Immunohistochemistry (Formalin-fixed Sections)

Recommended CD24 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
CD24 Molecule (CD24) Antikörper
  • CD24A
  • Cd24a
  • Cd24
  • HSA
  • Ly-52
  • nectadrin
  • CD24 molecule
  • CD24a antigen
  • CD24
  • Cd24
  • Cd24a
Reaktivität
Human
268
199
24
4
1
Wirt
Maus
206
173
75
1
Klonalität
Monoklonal
Konjugat
Dieser CD24 Antikörper ist unkonjugiert
54
50
34
18
12
11
8
7
6
6
6
6
6
5
4
4
4
4
4
4
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
Applikation
Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
358
102
95
80
54
48
33
26
21
19
8
6
5
4
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN302076
$ 303.60
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN192414 FACS IHC (f) PE Mouse IgG1 Anmelden zum Anzeigen SN3 11
1 ABIN192413 FACS IHC (f) FITC Mouse IgG1 Anmelden zum Anzeigen SN3 12
1 ABIN2749227 IHC (f) FACS APC Mouse IgG1 Anmelden zum Anzeigen SN3 11

General

Antigen CD24 Molecule (CD24) Antikörper
Reaktivität Human
(268), (199), (24), (4), (1)
Wirt Maus
(206), (173), (75), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser CD24 Antikörper ist unkonjugiert
(54), (50), (34), (18), (12), (11), (8), (7), (6), (6), (6), (6), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Applikation Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
(358), (102), (95), (80), (54), (48), (33), (26), (21), (19), (8), (6), (5), (4), (3), (2), (1), (1), (1)
Pubmed 10 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-CD24 Antikörper

Target Details CD24 Anwendungsinformationen Handhabung Referenzen für anti-CD24 Antikörper (ABIN302076) Bilder
Spezifität The antibody SN3 reacts with CD24, a 35-45 kDa heavily glycosylated cell surface antigen. CD24 is expressed by granulocytes, B lymphocytes and by some activated T cells and T cell malignancies. It is not expressed on human thymocytes.
HLDA IV, WS Code B 136
HLDA V, WS Code B CD24.7
Reinigung Purified by protein A
Reinheit > 95 % (by SDS-PAGE)
Immunogen Glycoproteins purified from human NALM-1 cell line.
Klon SN3
Isotyp IgG1

Target Details CD24

Produktdetails anti-CD24 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-CD24 Antikörper (ABIN302076) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD24 (CD24 Antibody Abstract)
Hintergrund CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4, it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid.
Forschungsgebiet CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation

Anwendungsinformationen

Produktdetails anti-CD24 Antikörper Target Details CD24 Handhabung Referenzen für anti-CD24 Antikörper (ABIN302076) Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CD24 Antikörper Target Details CD24 Anwendungsinformationen Referenzen für anti-CD24 Antikörper (ABIN302076) Bilder zurück nach oben
Konzentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Handhabung Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.

Referenzen für anti-CD24 Antikörper (ABIN302076)

Produktdetails anti-CD24 Antikörper Target Details CD24 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Všianská, Říhová, Varmužová, Suská, Kryukov, Mikulášová, Kupská, Penka, Pour, Adam, Hájek: "Analysis of B-cell subpopulations in monoclonal gammopathies." in: Clinical lymphoma, myeloma & leukemia, Vol. 15, Issue 4, pp. e61-71, 2015

Maliar, Servais, Waks, Chmielewski, Lavy, Altevogt, Abken, Eshhar: "Redirected T cells that target pancreatic adenocarcinoma antigens eliminate tumors and metastases in mice." in: Gastroenterology, Vol. 143, Issue 5, pp. 1375-84.e1-5, 2012

Solvason, Kearney: "The human fetal omentum: a site of B cell generation." in: The Journal of experimental medicine, Vol. 175, Issue 2, pp. 397-404, 1992

Fischer, Majdic, Gadd, Knapp: "Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 144, Issue 2, pp. 638-41, 1990

Barcos, Pollard, Fukukawa, Seon: "Follicular mantle zone cell subpopulations detected by monoclonal antibody SN3." in: Hematological oncology, Vol. 4, Issue 4, pp. 251-9, 1987

Fukukawa, Matsuzaki, Haruta, Hara, Seon: "New monoclonal antibodies SN3, SN3a, and SN3b directed to sialic acid of glycoprotein on human non-T leukemia cells." in: Experimental hematology, Vol. 14, Issue 9, pp. 850-5, 1986

Allgemeine Veröffentlichungen

Runz, Mierke, Joumaa, Behrens, Fabry, Altevogt: "CD24 induces localization of beta1 integrin to lipid raft domains." in: Biochemical and biophysical research communications, Vol. 365, Issue 1, pp. 35-41, 2007

Chou, Jeng, Lee, Hu, Kao, Lin, Lai, Hu, Yuan: "Cytoplasmic CD24 expression is a novel prognostic factor in diffuse-type gastric adenocarcinoma." in: Annals of surgical oncology, Vol. 14, Issue 10, pp. 2748-58, 2007

Keller, Rupp, Stoeck, Runz, Fogel, Lugert, Hager, Abdel-Bakky, Gutwein, Altevogt: "CD24 is a marker of exosomes secreted into urine and amniotic fluid." in: Kidney international, Vol. 72, Issue 9, pp. 1095-102, 2007

Schabath, Runz, Joumaa, Altevogt: "CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells." in: Journal of cell science, Vol. 119, Issue Pt 2, pp. 314-25, 2006

Bilder

Produktdetails anti-CD24 Antikörper Target Details CD24 Anwendungsinformationen Handhabung Referenzen für anti-CD24 Antikörper (ABIN302076) zurück nach oben
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-CD24 Molecule (CD24) antibody (ABIN302076) Surface staining of human peripheral blood cells with anti-CD24 (SN3) Alexa Fluor®...