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High cholesterol can reduce the protein expression of BK channel beta1 subunit in rabbit Oddi's sphincter (SO) cells which suggests high cholesterol can affect the function of BKca channel [BK channel beta1 subunit]
Aldosterone does not contribute to the regulation of BK channel expression/activity in response to dietary K(+) loading.
These data outline a new signaling mechanism by which KCa1.1 regulates beta1-integrin function and therefore invasiveness of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs).
These results provide further insights into the mechanism of modulation of the different N-terminal regions of the BKCa channel by beta-subunits.
Implicating both KCa1.1 and KCa3.1 (zeige KCNN4 ELISA Kits) channels.
These results identify KCa1.1 channels as crucial regulators of skeletal myogenesis.
Results show that reduced miR-17 expression is correlated with increased expression of KCNMA1 in malignant pleural mesothelioma. Computational analysis identified KCNMA1 gene is a direct target of miR-17.
Our report defines a novel autosomal recessive KCNMA1-related epileptic phenotype that encompasses cerebellar atrophy without paroxysmal dyskinesia, and highlights the sensitivity of the developing brain to both increased and decreased activity of the KCNMA1-encoded channels
A directed proteomic approach discovered the novel interaction of BKCa with Tom22 (zeige TOMM22 ELISA Kits), a component of the mitochondrion outer membrane import system, and the adenine nucleotide translocator (zeige SLC25A4 ELISA Kits) (ANT).
GSK3b (zeige GSK3b ELISA Kits) may up-regulate BK channels, an effect disrupted by lithium or additional expression of AKT (zeige AKT1 ELISA Kits) and possibly participating in the regulation of cell volume and excitability.
MiR (zeige MLXIP ELISA Kits)-31 represses KCNMA1 expression.
By introducing lanthanide binding tags in the extracellular region of the alpha- or beta1-subunit, we determined (i) a basic extracellular map of the BK channel, (ii) beta1-subunit-induced rearrangements of the voltage sensor in alpha-subunits, and (iii) the relative position of the beta1-subunit within the alpha/beta1-subunit complex.
Slo1 channels in the lysosome are required for refilling lysosomal Ca(2 (zeige CA2 ELISA Kits)+) stores.
Dynamic coupling between TRPV4 (zeige TRPV4 ELISA Kits) and Ca(2 (zeige CA2 ELISA Kits)+)-activated SK1 (zeige SPHK1 ELISA Kits)/3 and IK1 (zeige KCNN4 ELISA Kits) K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 in kidney collecting duct cells.
The differential regulation of ROMK (zeige KCNJ1 ELISA Kits), large-conductance Ca(2 (zeige CA2 ELISA Kits)+)-activated K(+) (BK) channel, BK-alpha and NKCC2 (zeige SLC12A1 ELISA Kits) between female and male mice, at least, were partly mediated via WNK1 (zeige WNK1 ELISA Kits) pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.
KCNMA1 contributes to the regulation of insulin (zeige INS ELISA Kits) signalling in mature adipocytes
Results showed that BK-knockout osteoblasts displayed low proliferation and impaired mineralization ability providing further evidence that BK channel is critical for osteoblast function.
Data, including data from studies in knockout mice, suggest that association/disassociation of subunits Kcnma1 and Kcnab1 (zeige KCNAB1 ELISA Kits) of the BK channel (large-conductance calcium-activated potassium channel (zeige KCNAB2 ELISA Kits)) is involved in function of coronary artery smooth muscle cells and their dysfunction during ischemia/reperfusion-induced myocardial injury in diabetes.
This study demonstrated that The interaction of MaxiK channel with GAT3 (zeige SLC6A13 ELISA Kits) opens the possibility of a role of MaxiK channel in GABA homeostasis and signaling.
the enhanced effect of amiloride on potassium secretion in wild-type compared to knockout mice on the alkaline diet clarify a BK- alpha/beta4-mediated potassium secretory pathway in intercalated cells driven by ENaC (zeige SCNN1A ELISA Kits)-mediated sodium reabsorption
Data suggest that the ion channels CaV1.3, bestrophin-1 and maxiK were identified as players in the regulation of photoreceptor outer segments (POS) phagocytosis by the retinal pigment epithelium (RPE).
analysis of SLO3 K+ channels shows evolutionary divergence for an RCK1 region of critical function
A neural-specific splice-variant exon of Slo serves as a gain-of-function module and allows physiologically relevant levels of membrane potential and intracellular calcium to activate the resultant channel effectively during Xenopus embryogenesis.
Porcine K2P3.1 (zeige KCNK3 ELISA Kits) channels exhibit atrial expression and functional properties similar to their human orthologs, supporting a general role as antiarrhythmic drug targets.
Inositol trisphosphate is an activator of BKCA channels in porcine coronary smooth muscle cells and exerts a coronary artery-relaxing effect.
Testerone-induced relaxation of endothelium-denuded coronary arteries is mediated, at least in part, by enhanced NO production, leading to cGMP synthesis and PKG (zeige PRKG1 ELISA Kits) activation, which, in turn, opens BK(Ca) channels.
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
calcium-activated potassium channel subunit alpha 1
, potassium large conductance calcium-activated channel, subfamily M, alpha member 1
, pulmonary calcium activated potassium channel
, calcium-activated potassium channel subunit alpha-1-like
, BK channel
, BKCA alpha
, calcium-activated potassium channel subunit alpha-1
, calcium-activated potassium channel, subfamily M subunit alpha-1
, large conductance calcium-activated potassium channel alpha subunit
, maxi K channel
, slo homolog
, slowpoke homolog
, BK channel alpha subunit
, BKCA alpha subunit
, maxi-K channel HSLO
, stretch-activated Kca channel
, calcium-activated potassium channel alpha subunit
, MaxiK calcium-activated potassium channel
, calcium activated potassium channel protein
, large conductance calcium-activated potassium channel subfamily M alpha member 1
, large conductance calcium-activated potassium (BK) channel alpha subunit a