LRRK2 Proteine (LRRK2)

Bezeichnung:
Leucine-Rich Repeat Kinase 2 Proteine (LRRK2)
Auf www.antikoerper-online.de finden Sie aktuell 0 Leucine-Rich Repeat Kinase 2 (LRRK2) Proteine von unterschiedlichen Herstellern. Insgesamt sind aktuell 0 LRRK2 Produkte verfügbar.
Synonyme:
4921513O20Rik, 9330188B09Rik, AURA17, AW561911, cI-46, D630001M17Rik, DARDARIN, Gm927, LRRK2, PARK8, RIPK7, ROCO2
alle Proteine anzeigen Gen GeneID UniProt
Human LRRK2 LRRK2 120892 Q5S007
Maus LRRK2 LRRK2 66725 Q5S006
Ratte LRRK2 LRRK2 300160  

Weitere Synonyme anzeigen

Weitere Proteine zu LRRK2 Interaktionspartnern

Zebrafish Leucine-Rich Repeat Kinase 2 (LRRK2) Interaktionspartner

  1. our similar early study and recent confirming experiments using the same reagents reported by Sheng et al. failed to reproduce the phenotype of the loss of dopaminergic neurons, although the mRNA of LRRK2 was molecularly disrupted

  2. results demonstrate that zLRRK2 is an ortholog of hLRRK2 and that the deletion of WD40 domain (zeige DCAF12L2 Proteine) of zLRRK2 provides a disease model for PD

Human Leucine-Rich Repeat Kinase 2 (LRRK2) Interaktionspartner

  1. we conclude that LRRK2 G2019S mutation most likely originated in a Berber founder who lived at least 5000 years ago.

  2. We discovered a new missense mutation in the LRRK2 gene, c.4321C>A (p.R1441S). LRRK2 p.R1441S represents the fourth pathogenic mutation observed within codon 1441 and its discovery adds to the remarkable complexity of a mutational hotspot within the ROC domain of the LRRK2 protein

  3. The Parkinson's disease-associated LRRK2 mutant G2019S impairs DRD1 (zeige DRD1 Proteine) internalization, leading to an alteration in signal transduction. The mutant forms of LRRK2 also affect receptor turnover by decreasing the rate of DRD2 (zeige DRD2 Proteine) trafficking from the Golgi complex to the cell membrane.

  4. we have identified a novel genetic association between the autophagy-related LRRK2 gene and susceptibility to SLE.

  5. There was no significant difference between nonmanifesting family members with and without a LRRK2 mutation in any of the 5 HRV parameters investigated.

  6. These results indicate that LRRK2 and alpha-synuclein participate in the dysregulation of CADPS2 (zeige CADPS2 Proteine) by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as Parkinson's disease.

  7. each mutation in LRRK2 and ARHGEF7 (zeige ARHGEF7 Proteine) demonstrated its unique functional property, which may contribute to the pathogenesis of Parkinson disease

  8. the important contribution of LRRK2 G2019S mutations to parkinsonism in Brazilian families.

  9. propose that the interplay between LRRK2 and p62 (zeige GTF2H1 Proteine) may contribute to the pathophysiological function and homeostasis of LRRK2 protein

  10. Mutation in the PARK8 locus encoding for the leucine-rich repeated kinase 2 protein (LRRK2 also named dardarin) is the most frequent cause of autosomal-dominant forms of Parkinson's disease.

Mouse (Murine) Leucine-Rich Repeat Kinase 2 (LRRK2) Interaktionspartner

  1. The Parkinson's disease-associated LRRK2 mutant G2019S impairs DRD1 (zeige DRD1 Proteine) internalization, leading to an alteration in signal transduction. The mutant forms of LRRK2 also affect receptor turnover by decreasing the rate of DRD2 (zeige DRD2 Proteine) trafficking from the Golgi complex to the cell membrane.

  2. LRRK2 negatively regulates the clearance of alphaSYN accompanied by down-regulation of the endocytosis pathway; LRRK2 in microglia may function as the offending molecule responsible for neurodegeneration, in terms of down-regulation of alphaSYN clearance.

  3. In addition to disease modeling, leucine-rich repeat kinase 2 (LRRK2) konckin (KI) mice represent a valuable resource for pharmacological studies.

  4. These results of this study demonstrate that alpha-synuclein inclusion formation in neurons can be blocked and that novel therapeutic compounds targeting this process by inhibiting LRRK2 kinase activity may slow progression of PD-associated pathology.

  5. The findings of this study indicated that the G2019S mutation of LRRK2 imparts a gain-of-abnormal function to striatal spiny projection neurons activity and morphology during a stage of development when activity can permanently modify circuit structure and function.

  6. LRRK2 is expressed in enteric neurons and related to alterations of neuronal peptides and IgA.

  7. our findings reveal a previously unknown regulatory role for LRRK2 in CX3CR1 (zeige CX3CR1 Proteine) signalling and suggest that an increase of CX3CR1 (zeige CX3CR1 Proteine) activity contributes to the attenuated inflammatory responses in Lrrk2-null microglia

  8. this study reveals that LRRK2 is a new positive regulator of Rip2 and promotes inflammatory cytokine induction through the Nod1/2-Rip2 pathway.

  9. LRRK2 kinase activity in microglia can contribute to neuroinflammation in Parkinson's disease via phosphorylating p53 (zeige TP53 Proteine) at T304 and T377 site

  10. an altered sphingolipid composition in Lrrk2(-/-) mouse brains, is reported.

Pig (Porcine) Leucine-Rich Repeat Kinase 2 (LRRK2) Interaktionspartner

  1. show that the LRRK2 sequence and expression patterns are conserved between pig and human

LRRK2 Protein Überblick

Protein Überblick

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

Alternative names and synonyms associated with LRRK2

  • leucine-rich repeat kinase 2 (lrrk2)
  • leucine-rich repeat kinase 2 (LRRK2)
  • leucine-rich repeat kinase 2 (Lrrk2)
  • 4921513O20Rik Protein
  • 9330188B09Rik Protein
  • AURA17 Protein
  • AW561911 Protein
  • cI-46 Protein
  • D630001M17Rik Protein
  • DARDARIN Protein
  • Gm927 Protein
  • LRRK2 Protein
  • PARK8 Protein
  • RIPK7 Protein
  • ROCO2 Protein

Bezeichner auf Proteinebene für LRRK2

leucine-rich repeat serine/threonine-protein kinase 2 , leucine-rich repeat kinase 2 , leucine-rich repeat serine/threonine-protein kinase 2-like , augmented in rheumatoid arthritis 17

GENE ID SPEZIES
559366 Danio rerio
745893 Pan troglodytes
100137384 Papio anubis
100145062 Xenopus (Silurana) tropicalis
100440374 Pongo abelii
100548936 Meleagris gallopavo
120892 Homo sapiens
66725 Mus musculus
300160 Rattus norvegicus
486608 Canis lupus familiaris
535652 Bos taurus
780403 Sus scrofa
Haben Sie etwas anderes gesucht?