anti-SMURF1 (SMURF1) Antikörper

anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 Antikörper (SMURF1)
Auf finden Sie aktuell 109 SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) Antikörper von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SMURF1 Proteine (5) und SMURF1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 127 SMURF1 Produkte verfügbar.
4930431E10Rik, mKIAA1625, RGD1309707
Alle Antikörper anzeigen Gen GeneID UniProt
SMURF1 57154 Q9HCE7
SMURF1 75788 Q9CUN6
SMURF1 690516  

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Meistgesuchte Reaktivitäten zu anti-SMURF1 (SMURF1) Antikörper

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anti-Human SMURF1 Antikörper:

anti-Mouse (Murine) SMURF1 Antikörper:

anti-Rat (Rattus) SMURF1 Antikörper:

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Am meisten referenzierte anti-SMURF1 Antikörper

  1. Human Polyclonal SMURF1 Primary Antibody für IHC (p), WB - ABIN388828 : Tajima, Goto, Yoshida, Shinomiya, Sekimoto, Yoneda, Miyazono, Imamura: Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7. in The Journal of biological chemistry 2003 (PubMed)
    Zeige alle 8 Referenzen für 388828

  2. Human Polyclonal SMURF1 Primary Antibody für EIA, IHC (p) - ABIN357469 : Suzuki, Murakami, Fukuchi, Shimanuki, Shikauchi, Imamura, Miyazono: Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. in The Journal of biological chemistry 2002 (PubMed)
    Zeige alle 6 Referenzen für 357469

  3. Human Polyclonal SMURF1 Primary Antibody für IHC (p), WB - ABIN388829 : Ebisawa, Fukuchi, Murakami, Chiba, Tanaka, Imamura, Miyazono: Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. in The Journal of biological chemistry 2001 (PubMed)
    Zeige alle 5 Referenzen für 388829

  4. Human Monoclonal SMURF1 Primary Antibody für IF, WB - ABIN2838593 : Franke, Balschun, Sina, Ellinghaus, Häsler, Mayr, Albrecht, Wittig, Buchert, Nikolaus, Gieger, Wichmann, Sventoraityte, Kupcinskas, Onnie, Gazouli, Anagnou, Strachan, McArdle, Mathew, Rutgeerts, Vermeire, Vatn, , Krawczak, Rosenstiel, Karlsen, Schreiber: Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). in Nature genetics 2010 (PubMed)
    Zeige alle 5 Referenzen für 2838593

  5. Human Polyclonal SMURF1 Primary Antibody für EIA, WB - ABIN954864 : Alarcón, Zaromytidou, Xi, Gao, Yu, Fujisawa, Barlas, Miller, Manova-Todorova, Macias, Sapkota, Pan, Massagué: Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. in Cell 2009 (PubMed)
    Zeige alle 4 Referenzen für 954864

  6. Human Monoclonal SMURF1 Primary Antibody für IF, IHC (p) - ABIN566098 : Murakami, Mathew, Huang, Farahani, Peng, Olson, Etlinger: Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension. in Experimental biology and medicine (Maywood, N.J.) 2010 (PubMed)
    Zeige alle 2 Referenzen für 566098

  7. Human Polyclonal SMURF1 Primary Antibody für ELISA, WB - ABIN185500 : Ozdamar, Bose, Barrios-Rodiles, Wang, Zhang, Wrana: Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. in Science (New York, N.Y.) 2005 (PubMed)

Weitere Antikörper gegen SMURF1 Interaktionspartner

Human SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) Interaktionspartner

  1. SMU (zeige MLXIP Antikörper)RF1 is increased in patients with pulmonary arterial hypertension

  2. Data suggest that SMURF1 is required for S phase progression; SMURF1 promotes ubiquitination-dependent degradation of WEE1 (zeige WEE1 Antikörper); these functions of SMURF1 appear to be linked and may be important in cell proliferation and tumorigenesis. (SMURF1 = SMAD specific E3 ubiquitin protein ligase 1; WEE1 (zeige WEE1 Antikörper) = wee 1 (zeige WEE1 Antikörper) homolog [S pombe] protein)

  3. Taken together, our study for the first time clarified that the E3 ligase Smurf1 regulates USP5 protein stability and USP5-mediated TNF-alpha production through the ubiquitin proteasome pathway.

  4. results reveal the regulatory circuit between RUNX2 (zeige RUNX2 Antikörper) and SMURF1 controls RUNX2 (zeige RUNX2 Antikörper) expression and regulates odntoblastic differentiation in hDPSCs.

  5. EGF (zeige EGF Antikörper)/Smurf1 inhibits Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper)-induced osteogenic differentiation and that Smurf1 downregulates Wnt/b-catenin signaling by enhancing proteasomal degradation of beta-catenin (zeige CTNNB1 Antikörper).

  6. a model that CD166 (zeige ALCAM Antikörper) regulates MCAM (zeige MCAM Antikörper) through a signaling flow from activation of PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) and c-Raf (zeige RAF1 Antikörper)/MEK (zeige MAP2K1 Antikörper)/ERK (zeige EPHB2 Antikörper) signaling to the inhibition of potential MCAM (zeige MCAM Antikörper) ubiquitin E3 ligases, betaTrCP (zeige BTRC Antikörper) and Smurf1.

  7. SND1 (zeige SND1 Antikörper) promoted expression of the E3 ubiquitin ligase Smurf1, leading to RhoA (zeige RHOA Antikörper) ubiquitination and degradation.

  8. NF-kappaB (zeige NFKB1 Antikörper) bind to the -411 to -420 region of the SMURF1 promoter and plays an essential role in the expression of SMURF1.

  9. Smurf1 determines cell apoptosis rates downstream of DNA damage-induced ATR/Chk1 signalling by promoting degradation of RhoB.

  10. The role of SMURF1 and inhibition of BMP signaling in maintaining a CSC-like population was confirmed by the loss of a CD44 (zeige CD44 Antikörper)(high) expressing.

Mouse (Murine) SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) Interaktionspartner

  1. demonstration that Smurf1 acts as a brake for integrin activation by controlling Kindlin-2 (zeige FERMT2 Antikörper) protein levels, a new mechanism that permits precise modulation of integrin-mediated cellular functions

  2. miR (zeige MLXIP Antikörper)-140-5p and SMURF1 are key regulators of disease pathology in pulmonary arterial hypertension

  3. Smurf1 is required for selective autophagy of Mycobacterium tuberculosis and host defense against tuberculosis infection.

  4. Smurf1 regulates glucose metabolism and inhibits osteoblast differentiation. Smurf1 function requires the presence of serine 148 (S148) in Smurf1.

  5. Smurf1 mediates NGF (zeige NGFB Antikörper) signaling and ubiquitinates RhoA (zeige RHOA Antikörper) in growth cones, regulating the need for local translation and degradation.

  6. Smurf-mediated endocytosis of Patched1 (zeige PTCH1 Antikörper) is required in sonic hedgehog (zeige SHH Antikörper) signal reception

  7. Inhibition of rhBMP-2-induced ALP (zeige CCL21A Antikörper) activity by intracellular delivery of SMURF1 in murine calvarial preosteoblast cells.

  8. Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 (zeige AXIN1 Antikörper) negatively regulates Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.

  9. These results suggest that the JNK (zeige MAPK8 Antikörper)/AP-1 (zeige JUN Antikörper) and ERK (zeige EPHB2 Antikörper)/Runx2 (zeige RUNX2 Antikörper) signaling pathways mediate TNF-alpha (zeige TNF Antikörper)-dependent Smurf1 transcription.

  10. Smurf1 is a negative feedback regulator for IFN-gamma (zeige IFNG Antikörper) signaling by targeting STAT1 (zeige STAT1 Antikörper) for ubiquitination and proteasomal degradation.

Xenopus laevis SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) Interaktionspartner

  1. Data demonstrate that Smurf1 and Smurf2 (zeige SMURF2 Antikörper) have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.

  2. In Xenopus embryos, the BMP pathway is a major physiological target of Smurf1. We propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm.

SMURF1 Antigen-Profil

Beschreibung des Gens

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with SMURF1

  • SMAD specific E3 ubiquitin protein ligase 1 (SMURF1) Antikörper
  • SMAD specific E3 ubiquitin protein ligase 1 (LOC100220332) Antikörper
  • SMAD specific E3 ubiquitin protein ligase 1 (smurf1) Antikörper
  • SMAD specific E3 ubiquitin protein ligase 1 (Smurf1) Antikörper
  • 4930431E10Rik Antikörper
  • mKIAA1625 Antikörper
  • RGD1309707 Antikörper

Bezeichner auf Proteinebene für SMURF1

Smad ubiquitination regulatory factor 1 , E3 ubiquitin-protein ligase SMURF1 , SMAD specific E3 ubiquitin protein ligase 1 , e3 ubiquitin-protein ligase SMURF1-like , E3 ubiquitin ligase SMURF1 , SMAD-specific E3 ubiquitin-protein ligase 1 , Smad-specific E3 ubiquitin ligase 1 , hSMURF1 , SMAD ubiquitination regulatory factor 1 , xSMURF1

416487 Gallus gallus
513902 Bos taurus
608821 Canis lupus familiaris
100063241 Equus caballus
472670 Pan troglodytes
718616 Macaca mulatta
100081555 Ornithorhynchus anatinus
100220332 Taeniopygia guttata
100456599 Pongo abelii
100465094 Ailuropoda melanoleuca
100540915 Meleagris gallopavo
100556808 Anolis carolinensis
57154 Homo sapiens
75788 Mus musculus
100621443 Sus scrofa
690516 Rattus norvegicus
398131 Xenopus laevis
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