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Data indicate that plexin A1-4 (PLXNA1-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
in vitro analysis on PLXNA3 also suggest that this gene may have some form of growth suppressive role in breast cancer, in addition to a similar role for the gene previously reported in ovarian cancer.
Data show that the expression of Sema3A (zeige SEMA3A ELISA Kits) receptors (neuropilin-1 (NRP-1 (zeige NRP1 ELISA Kits)), NRP-2 (zeige NELL2 ELISA Kits), plexin A1, plexin A2 (zeige Plxna2 ELISA Kits), and plexin A3) significantly increased during M-CSF (zeige CSF1 ELISA Kits)-mediated differentiation of monocytes into macrophages.
genetic findings demonstrate that Sema3a (zeige SEMA3A ELISA Kits) repellent signaling plays a role in the establishment of proper afferent projections in SAG (zeige RNF7 ELISA Kits) neurons, and this signaling likely occurs through a receptor complex involving Npn1 (zeige NRP1 ELISA Kits) and either plexinA1 or plexinA3
plexin-A3 and plexin-A4 (zeige PLXNA4 ELISA Kits) are expressed in newly-differentiated sympathetic neurons, but not their neural crest precursors. They function cooperatively to regulate the migration of sympathetic neurons and then differentially to guide the sympathetic axons.
These results indicate that the stereotyped pruning of the visual and motor CST (zeige CORT ELISA Kits) axon collaterals is differentially regulated and that this specificity arises from the differential expression of plexin receptors in the cortex.
the signaling of plexin-A3, plexin-A4 (zeige PLXNA4 ELISA Kits), and Sema6A (zeige SEMA6A ELISA Kits) is at least partially required for dorsal turning of the corticospinal tract axons
The combined loss of PLXNA3 and PLXNA4 (zeige PLXNA4 ELISA Kits) impaired facial branchiomotor axon guidance more severely than loss of either plexin alone, suggesting that SEMA3A (zeige SEMA3A ELISA Kits) and SEMA3F (zeige SEMA3F ELISA Kits) signals, even though both essential, are partially redundant.
the plexin A3 GAP domain adopts a closed conformation and cannot accommodate R-Ras/M-Ras (zeige MRAS ELISA Kits) in its substrate-binding site, providing a structural basis for the autoinhibited state of plexins
\Homodimerization of PlxnA3 caused by mutation M1281L remains in the presence of ligand semaphorin 3F (zeige SEMA3F ELISA Kits) and co-receptor neuropilin (zeige NRP1 ELISA Kits)-2a.
Data show that null mutants of the guidance receptor plexin A3 display motor axon branching defects.
in vivo demonstration of the intersection of spontaneous electrical activity with the PlexinA3 guidance molecule receptor in regulation of axon pathfinding
study shows plexinA3 is a crucial receptor for axon guidance cues in primary motor neurons
Plexin A3 plays an additional role in motor axonal morphogenesis.
Plxna3 acts with its ligand Sema3a1 for fasciculation and correct target selection of the Vp and VII (zeige TH ELISA Kits) motor axons.
The protein encoded by this gene is a member of the plexin class of proteins. The encoded protein is a transmembrane protein that is exposed on the cell surface. This gene is thought to be involved in epithelial and neural tissue development.
, Sex chromosome X transmembrane protein of HGF receptor family 3
, semaphorin receptor SEX
, plexin 3
, Plexin 4, SEX, homolog to the cMet/HGF receptors