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anti-Human Osteopontin Antikörper:
anti-Mouse (Murine) Osteopontin Antikörper:
anti-Rat (Rattus) Osteopontin Antikörper:
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Human Monoclonal Osteopontin Primary Antibody für ICC, IF - ABIN259958
Kon, Yokosaki, Maeda, Segawa, Horikoshi, Tsukagoshi, Rashid, Morimoto, Inobe, Shijubo, Chambers, Uede: Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. in Journal of cellular biochemistry 2002
Show all 15 Pubmed References
Human Polyclonal Osteopontin Primary Antibody für ELISA, ICC - ABIN250537
Alonso, Tracey, Ortiz, Pérez-Gómez, Palacios, Pollán, Linares, Serrano, Sáez-Castillo, Sánchez, Pajares, Sánchez-Aguilera, Artiga, Piris, Rodríguez-Peralto: A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis. in Cancer research 2007
Show all 4 Pubmed References
Dog (Canine) Polyclonal Osteopontin Primary Antibody für IHC (p), IP - ABIN153090
Kim, Shin: Immunohistochemical study of osteopontin in boar testis. in Journal of veterinary science 2007
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Human Polyclonal Osteopontin Primary Antibody für IHC (fp), IHC - ABIN105163
Ashkar, Weber, Panoutsakopoulou, Sanchirico, Jansson, Zawaideh, Rittling, Denhardt, Glimcher, Cantor: Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. in Science (New York, N.Y.) 2000
Show all 18 Pubmed References
Mouse (Murine) Polyclonal Osteopontin Primary Antibody für IF (cc), IF (p) - ABIN723800
Zhang, Men, Fu, Shan, Ye, Wu, Tao, Liu, Jiang: Contribution of SATB2 to the stronger osteogenic potential of bone marrow stromal cells from craniofacial bones. in Cell and tissue research 2012
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Mouse (Murine) Polyclonal Osteopontin Primary Antibody für IHC (p), WB - ABIN3042687
Zhou, Jin, Li, Zhao, Zhang, Wang, Li, Zhang, Xiang: Total flavonoids of Desmodium styracifolium attenuates the formation of hydroxy-L-proline-induced calcium oxalate urolithiasis in rats. in Urolithiasis 2017
Show all 2 Pubmed References
Human Monoclonal Osteopontin Primary Antibody für ICC, IHC - ABIN1098149
Liersch, Gerss, Schliemann, Bayer, Schwöppe, Biermann, Appelmann, Kessler, Löwenberg, Büchner, Hiddemann, Müller-Tidow, Berdel, Mesters: Osteopontin is a prognostic factor for survival of acute myeloid leukemia patients. in Blood 2012
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Human Polyclonal Osteopontin Primary Antibody für IHC (fp), IHC - ABIN1043686
Aita, Barrera, Reniero, Lopez, Biglione, Weisburd, Rajmil, Largacha, Ritacco: Hospital transmission of multidrug-resistant Mycobacterium tuberculosis in Rosario, Argentina. in Medicina 1996
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Dog (Canine) Polyclonal Osteopontin Primary Antibody für EIA, IHC (p) - ABIN118005
Yamasaki, Nair, Bhattacharya, Yamamoto, Kurazono, Takeda: Cryptic appearance of a new clone of Vibrio cholerae serogroup 01 biotype El Tor in Calcutta, India. in Microbiology and immunology 1997
Show all 14 Pubmed References
Human Polyclonal Osteopontin Primary Antibody für IF (p), IHC (p) - ABIN723695
Liu, Zhang, Wang, Zhang, Chen, Wu: A Strontium-Modified Titanium Surface Produced by a New Method and Its Biocompatibility In Vitro. in PLoS ONE 2015
In Osteoarthritis tissues, OPN mRNA, and NEAT1 expression was upregulated, whereas miR (zeige MLXIP Antikörper)-181c expression was downregulated, indicating that targeting NEAT1 to rescue miR (zeige MLXIP Antikörper)-181c expression so as to inhibit OPN expression and synoviocyte proliferation
IL-6 (zeige IL6 Antikörper) and sIL (zeige PMEL Antikörper)-6R induced by IL-1beta (zeige IL1B Antikörper) may trigger IL-6 (zeige IL6 Antikörper) trans-signaling, contributing to the upregulation of OPN in THP-1 (zeige GLI2 Antikörper) macrophages. Macrophages may be used as a source of IL-6 (zeige IL6 Antikörper) and sIL (zeige PMEL Antikörper)-6R and evoke IL-6 (zeige IL6 Antikörper) trans-signaling.
OPN is a key mediator of intracerebral tumor growth, invasion, and dissemination in central nervous system lymphoma, and these effects depend upon activation of NF-kappaB (zeige NFKB1 Antikörper).
These observations provided evidence on the protective role of OPN in pancreatic islets under diabetic condition, and may point to novel therapeutic targets for islet protection in T2D.
Osteopontin, neopterin, and myeloperoxidase (zeige MPO Antikörper) were independently associated with the risk of recurrent stroke and improved risk classification when added to a clinical risk algorithm
The findings of an excess of inhibitory OPN near osteocytes and their cell processes, and in dentin, spatially correlates with the defective mineralization observed at these sites in the skeleton and teeth of X-linked hypophosphatemia patients.
Simvastatin reversed IL-13 (zeige IL13 Antikörper)-suppressed adenosine deaminase (zeige ADA Antikörper) activity, leading to the down-regulation of adenosine signaling and inhibition osteopontin expression through the direct inhibition of IL-13 (zeige IL13 Antikörper)-activated STAT6 (zeige STAT6 Antikörper) pathway in COPD (zeige ARCN1 Antikörper).
Epistatic effects of SPP (zeige SPEB Antikörper) rs4754 with SPARC (zeige SPARC Antikörper) polymorphisms are associated with gastric carcinogenesis.
this study indicates that OPN can induce epithelial-mesenchymal transition of hepatocellular carcinoma cells through increasing vimentin (zeige VIM Antikörper) stability
This review summarizes the current understanding of OPN in liver diseases. Further understanding of the pathophysiological role of OPN in cellular interactions and molecular mechanisms associated with hepatic inflammation, fibrosis and cancer may contribute to the development of novel strategies for clinical diagnosis, monitoring and therapy of liver diseases.
Data show that, together, osteocalcin (OC (zeige BGLAP Antikörper)) and osteopontin (OPN) play important roles in determining bone size, shape, and strength.
Results show that BSP (zeige KLK6 Antikörper) and OPN are present in the mineralized tissues of fibrocartilaginous enthuses.
AMPK (zeige PRKAA1 Antikörper) was sufficient to stimulate osteogenesis of MC3T3-E1 cells and inhibit adipogenesis of 3T3-L1 cells through the AMPK (zeige PRKAA1 Antikörper)-Gfi1 (zeige ZNF163 Antikörper)-OPN axis.
Excess osteopontin exacerbated sarcolemmal injury, and correspondingly, that loss of osteopontin reduced injury extent both in isolated myofibers and in muscle.
A MMP-9-cleaved OPN fragment, OPN-32kDa, was responsible for inducing expansion of myeloid-derived suppressor cells, which may contribute to 3LL tumor's evasion of the immune response.
OPN played a critical role in activating the migration of Mesenchymal stem cells to injured sites and their differentiation into specific skin cell types during skin wound healing.
Findings demonstrate that claudin-low mammary tumor cells rely on OPN for proliferation, survival and migration as knockdown of OPN using siRNA inhibited proliferation and migration while increasing apoptosis.
TSC1 (zeige TSC1 Antikörper)/TSC2 (zeige TSC2 Antikörper) complex upregulation of OPN expression is mediated by transcription factor SOX9 (zeige SOX9 Antikörper) in an mTOR (zeige FRAP1 Antikörper)-independent manner. Moreover, ablation of OPN by deficient TSC1 (zeige TSC1 Antikörper)/TSC2 (zeige TSC2 Antikörper) complex contributed to inactivation of AKT (zeige AKT1 Antikörper) in TSC (zeige SLC12A3 Antikörper) cells
Intracellular OPN (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted OPN (sOPN) increase the population size of lymphoid cells. The total effect of OPN on skewing the leukocyte population balance was observed as host sensitivity to early systemic infection with Candida albicans and T cell-mediated colitis.
this study shows that OPN promotes sepsis in Pseudomonas aeruginosa-infected mice and potentially blocks B cell-dependent immunity
This implies that a majority of the acidic residues within OPN must be engaged in calcium interaction under physiological conditions.
Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk.
Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
osteopontin (OPN) can serve as a process-directing agent for the intrafibrillar mineralization of collagen.
Results suggest a mechanism of the interaction of UO2(2+) with bone metabolism and a new role for osteopontin (OPN) as a metal transporter.
Upon induction of luteolysis, SPP1 serves as a signaling molecule to recruit or activate immune cells to facilitate luteal regression and tissue degradation.
OPN strongly reduces the amount of biofilm formed in a well-defined laboratory model of acidogenic dental biofilm.
This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs (zeige PTMS Antikörper)) compared to human Escherichia-coli-derived recombinant OPN without PTMs (zeige PTMS Antikörper).
topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein (zeige CRISP1 Antikörper)
the bovine osteopontin gene has two functionally distinct clusters of haplotypes within the QTL region on chromosome 6
These data suggested that methylation in the OPN promoter plays a crucial role in the regulation of OPN expression that we found in cloned pigs genome.
The striking breed differences between hyperprolific Large White and Meishanin pigs of secreted phospoprotein 1 expression in endometrium suggest that SPP1 may be associated with placental efficiency.
Microglia incubated in vitro with different concentrations (0.1 fM-1 nM) of recombinant osteopontin showed increased proliferation at 10 fM.
results of this study reveal faster growth rate and differences in pig productivity according to genotypes of the SPP1 gene
Osteopontin could play an important role in the development of neointimal hyperplasia in venous conduits after coronary artery bypass grafting.
A different MSSCP pattern was shown in osteopontin which indicates that mutation is located in promotor region; the A --> G transitions was identified in two positions -617 and -608
The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta (zeige CEBPB Antikörper) binding site and this binding site is negatively affected by the mutant G allele.
in pregnant pigs SPP1 is induced by conceptus estrogen in uterine luminal epithelium and is regulated in a manner coincident with placental progesterone production
osteopontin promotes pathologic mineralization via calcium pyrophosphate dihydrate crystal formation in articular cartilage.
Osteopontin is detected in the majority of germ cells and is involved in spermatogenesis in boar testis.
Infection of urinary tract by Escherichia coli caused higher than normal expression of promoter protein osteopontin and mucosal damage at renal tubular cells.
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.
, early T-lymphocyte activation 1
, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
, urinary stone protein
, 44 kDa bone phosphoprotein
, bone sialoprotein 1
, calcium oxalate crystal growth inhibitor protein
, early T-lymphocyte activation 1 protein
, osteopontin-like protein
, Sialoprotein (osteopontin)
, bone sialoprotein I
, spp1 protein
, secreted phosphoprotein-1
, LOW QUALITY PROTEIN: osteopontin