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anti-Human Osteopontin Antikörper:
anti-Mouse (Murine) Osteopontin Antikörper:
anti-Rat (Rattus) Osteopontin Antikörper:
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Human Monoclonal Osteopontin Primary Antibody für ICC, IF - ABIN259958
Kon, Yokosaki, Maeda, Segawa, Horikoshi, Tsukagoshi, Rashid, Morimoto, Inobe, Shijubo, Chambers, Uede: Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. in Journal of cellular biochemistry 2002
Show all 15 Pubmed References
Human Polyclonal Osteopontin Primary Antibody für IHC (fp), IHC - ABIN105163
Ashkar, Weber, Panoutsakopoulou, Sanchirico, Jansson, Zawaideh, Rittling, Denhardt, Glimcher, Cantor: Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. in Science (New York, N.Y.) 2000
Show all 18 Pubmed References
Human Polyclonal Osteopontin Primary Antibody für ELISA, ICC - ABIN250537
Alonso, Tracey, Ortiz, Pérez-Gómez, Palacios, Pollán, Linares, Serrano, Sáez-Castillo, Sánchez, Pajares, Sánchez-Aguilera, Artiga, Piris, Rodríguez-Peralto: A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis. in Cancer research 2007
Show all 4 Pubmed References
Dog (Canine) Polyclonal Osteopontin Primary Antibody für IHC (p), IP - ABIN153090
Kim, Shin: Immunohistochemical study of osteopontin in boar testis. in Journal of veterinary science 2007
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Mouse (Murine) Polyclonal Osteopontin Primary Antibody für IF (cc), IF (p) - ABIN723800
Zhang, Men, Fu, Shan, Ye, Wu, Tao, Liu, Jiang: Contribution of SATB2 to the stronger osteogenic potential of bone marrow stromal cells from craniofacial bones. in Cell and tissue research 2012
Show all 3 Pubmed References
Human Monoclonal Osteopontin Primary Antibody für ICC, IHC - ABIN1098149
Liersch, Gerss, Schliemann, Bayer, Schwöppe, Biermann, Appelmann, Kessler, Löwenberg, Büchner, Hiddemann, Müller-Tidow, Berdel, Mesters: Osteopontin is a prognostic factor for survival of acute myeloid leukemia patients. in Blood 2012
Show all 2 Pubmed References
Mouse (Murine) Polyclonal Osteopontin Primary Antibody für IHC (p), WB - ABIN3042687
Zhou, Jin, Li, Zhao, Zhang, Wang, Li, Zhang, Xiang: Total flavonoids of Desmodium styracifolium attenuates the formation of hydroxy-L-proline-induced calcium oxalate urolithiasis in rats. in Urolithiasis 2017
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Dog (Canine) Polyclonal Osteopontin Primary Antibody für EIA, IHC (p) - ABIN118005
Yamasaki, Nair, Bhattacharya, Yamamoto, Kurazono, Takeda: Cryptic appearance of a new clone of Vibrio cholerae serogroup 01 biotype El Tor in Calcutta, India. in Microbiology and immunology 1997
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Human Polyclonal Osteopontin Primary Antibody für IHC (fp), IHC - ABIN1043686
Aita, Barrera, Reniero, Lopez, Biglione, Weisburd, Rajmil, Largacha, Ritacco: Hospital transmission of multidrug-resistant Mycobacterium tuberculosis in Rosario, Argentina. in Medicina 1996
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Human Polyclonal Osteopontin Primary Antibody für IHC, IHC (p) - ABIN4341877
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
This review summarizes the current understanding of OPN in liver diseases. Further understanding of the pathophysiological role of OPN in cellular interactions and molecular mechanisms associated with hepatic inflammation, fibrosis and cancer may contribute to the development of novel strategies for clinical diagnosis, monitoring and therapy of liver diseases.
High SPP1 expression is associated with head and neck cancer.
High SPP1 expression is associated with castration-resistant progression in androgen dependent metastatic prostate cancer.
OPN expression pattern in leukemia cell line KG1a could be compatible with CD34 (zeige CD34 Antikörper)(+)/CD123 (zeige IL3RA Antikörper)(+) subtype enrichment by parthenolide, which in turn implies OPN's unique role in resistance of cell populations characterized by CD34 (zeige CD34 Antikörper)(+)/CD123 (zeige IL3RA Antikörper)(+) phenotype.
Osteopontin is elevated in patients with mitral annulus calcification.
OPN may serve as a prognostic factor and a potential target for therapy.
Upregulation of PD-L1 (zeige CD274 Antikörper) by SPP1 mediates macrophage polarization and facilitates immune escape in lung adenocarcinoma.
Expression and inactivation of osteopontin-degrading PHEX (zeige PHEX Antikörper) enzyme in squamous cell carcinoma
These results describe the pleiotropic roles of OPN in the tumor metastasis cascade, which indicate its potential as an effective target for both early and advanced tumors.
Osteopontin exon 4 was associated with a favorable response to tamoxifen, but a poor response to chemotherapy with CMF (cyclophosphamide, methotrexate, fluorouracil) in 119 Polish breast cancer patients.
These data suggested that methylation in the OPN promoter plays a crucial role in the regulation of OPN expression that we found in cloned pigs genome.
The striking breed differences between hyperprolific Large White and Meishanin pigs of secreted phospoprotein 1 expression in endometrium suggest that SPP1 may be associated with placental efficiency.
Microglia incubated in vitro with different concentrations (0.1 fM-1 nM) of recombinant osteopontin showed increased proliferation at 10 fM.
results of this study reveal faster growth rate and differences in pig productivity according to genotypes of the SPP1 gene
Osteopontin could play an important role in the development of neointimal hyperplasia in venous conduits after coronary artery bypass grafting.
A different MSSCP pattern was shown in osteopontin which indicates that mutation is located in promotor region; the A --> G transitions was identified in two positions -617 and -608
The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta (zeige CEBPB Antikörper) binding site and this binding site is negatively affected by the mutant G allele.
in pregnant pigs SPP1 is induced by conceptus estrogen in uterine luminal epithelium and is regulated in a manner coincident with placental progesterone production
osteopontin promotes pathologic mineralization via calcium pyrophosphate dihydrate crystal formation in articular cartilage.
Osteopontin is detected in the majority of germ cells and is involved in spermatogenesis in boar testis.
A MMP-9-cleaved OPN fragment, OPN-32kDa, was responsible for inducing expansion of myeloid-derived suppressor cells, which may contribute to 3LL tumor's evasion of the immune response.
OPN played a critical role in activating the migration of Mesenchymal stem cells to injured sites and their differentiation into specific skin cell types during skin wound healing.
Findings demonstrate that claudin-low mammary tumor cells rely on OPN for proliferation, survival and migration as knockdown of OPN using siRNA inhibited proliferation and migration while increasing apoptosis.
TSC1 (zeige TSC1 Antikörper)/TSC2 (zeige TSC2 Antikörper) complex upregulation of OPN expression is mediated by transcription factor SOX9 (zeige SOX9 Antikörper) in an mTOR (zeige FRAP1 Antikörper)-independent manner. Moreover, ablation of OPN by deficient TSC1 (zeige TSC1 Antikörper)/TSC2 (zeige TSC2 Antikörper) complex contributed to inactivation of AKT (zeige AKT1 Antikörper) in TSC (zeige SLC12A3 Antikörper) cells
Intracellular OPN (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted OPN (sOPN) increase the population size of lymphoid cells. The total effect of OPN on skewing the leukocyte population balance was observed as host sensitivity to early systemic infection with Candida albicans and T cell-mediated colitis.
this study shows that OPN promotes sepsis in Pseudomonas aeruginosa-infected mice and potentially blocks B cell-dependent immunity
observed a marked decrease of renal gene expression and urinary excretion of osteopontin in Npt2a (zeige SLC34A1 Antikörper)(-/-) mice
data suggest the possibility that Opn might regulate the homeostasis of intestinal microflora through maintenance of TCRgammadelta+ IELs, possibly by support of IEL survival
OPN secreted by follicular CD153 (zeige TNFSF8 Antikörper)(+) senescence-associated T cells in germinal centers (GCs (zeige UGCG Antikörper)) promotes a continuous supply of intracellular autoantigens via apoptotic cells, thus playing a key role in the progression of the autoreactive GC reaction and leading to pathogenic autoantibody production in lupus-prone mice.
study demonstrated an anti-tumorigenic role of OPN in transgenic adenocarcinoma of the mouse prostate (TRAMP (zeige DPT Antikörper)) development and also suggests that the contribution of OPN to tumor development depends on the type of tumor as well as the source and isoform of OPN
This implies that a majority of the acidic residues within OPN must be engaged in calcium interaction under physiological conditions.
Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk.
Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
osteopontin (OPN) can serve as a process-directing agent for the intrafibrillar mineralization of collagen.
Results suggest a mechanism of the interaction of UO2(2+) with bone metabolism and a new role for osteopontin (OPN) as a metal transporter.
Upon induction of luteolysis, SPP1 serves as a signaling molecule to recruit or activate immune cells to facilitate luteal regression and tissue degradation.
OPN strongly reduces the amount of biofilm formed in a well-defined laboratory model of acidogenic dental biofilm.
This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs (zeige PTMS Antikörper)) compared to human Escherichia-coli-derived recombinant OPN without PTMs (zeige PTMS Antikörper).
topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein (zeige CRISP1 Antikörper)
the bovine osteopontin gene has two functionally distinct clusters of haplotypes within the QTL region on chromosome 6
Infection of urinary tract by Escherichia coli caused higher than normal expression of promoter protein osteopontin and mucosal damage at renal tubular cells.
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000
, SPP1/CALPHA1 fusion
, early T-lymphocyte activation 1
, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
, urinary stone protein
, bone sialoprotein 1
, 44 kDa bone phosphoprotein
, calcium oxalate crystal growth inhibitor protein
, early T-lymphocyte activation 1 protein
, osteopontin-like protein
, Sialoprotein (osteopontin)
, bone sialoprotein I
, secreted phosphoprotein-1
, sphingosine-1-phosphatase 1