CDKL5 (CDKL5) ELISA Kits

Bezeichnung:
Cyclin-Dependent Kinase-Like 5 ELISA Kits (CDKL5)
Auf www.antikoerper-online.de finden Sie aktuell 0 Cyclin-Dependent Kinase-Like 5 (CDKL5) ELISA Kits von unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CDKL5 Antikörper (77) und CDKL5 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 86 CDKL5 Produkte verfügbar.
Synonyme:
BC038161, EIEE2, ISSX, Stk9
list all ELISA KIts Gen GeneID UniProt
Human CDKL5 CDKL5 6792 O76039
Maus CDKL5 CDKL5 382253 Q3UTQ8
Ratte CDKL5 CDKL5 100362725  

Weitere Synonyme anzeigen

Weitere ELISA Kits für CDKL5 Interaktionspartner

Human Cyclin-Dependent Kinase-Like 5 (CDKL5) Interaktionspartner

  1. We have characterised the predominant brain isoform of CDKL5, a 9.7 kb transcript comprised of 18 exons with a large 6.6 kb 3'-untranslated region (UTR (zeige UTS2R ELISA Kits)), which we name hCDKL5_1. In addition we describe new exonic regions and a range of novel splice and UTR (zeige UTS2R ELISA Kits) isoforms

  2. In the asymptomatic mother, the mutated copy of the CDKL5 gene was inactivated in 90% of blood cells. We also identified a premature stop codon (p.Arg926*) in IQSEC2 (zeige IQSEC2 ELISA Kits) in a patient with a Rett-like phenotype. Finally, exome sequencing enabled us to characterize a heterozygous de novo missense (p.Val408Ala) in KCNA2 (zeige KCNA2 ELISA Kits) in a girl with infantile-onset seizures variant of Rett syndrome (RTT)

  3. The results suggested the mutant CDKL5 was responsible for the Rett syndrome disease.

  4. Rett syndrome with early epilepsy and the congenital variant are mainly due to variations in the CDKL5 and FOXG1 (zeige FOXG1 ELISA Kits) genes, respectively

  5. Mutations in exon 8 of cyclin-dependent kinase-like 5 gene (zeige GPD1 ELISA Kits) were determined to be disease-causing in epileptic encephalopathy.

  6. study presents the genotype of 2 sisters, a CDKL5 mutation c. 283-3_290del, but different phenotype

  7. Data suggest that the increased dosage of cyclin dependent kinase like 5 protein(CDKL5) might have affected interactions of this kinase with its substrates, leading to perturbation of neurodevelopmental and neurobehavioral abnormalities.

  8. It was indicated that CDKL5 controls excitatory synaptic transmission and the conditions associated with CDKL5 deviation in man indicates synaptic abnormalities.

  9. CDKL5 gene mutations accounted for 5.4% of boys with early onset epileptic encephalopathy

  10. CDKL5 gene is not useful in practical molecular diagnosis of atypical Rett syndrome.

Mouse (Murine) Cyclin-Dependent Kinase-Like 5 (CDKL5) Interaktionspartner

  1. The data of this study demonstrate that dendritic spine stabilization is strongly regulated by CDKL5.

  2. Our findings demonstrate that CDKL5 is an important regulator of synaptic function in glutamatergic neurons and serves a critical role in learning and memory.

  3. Nuclear HDAC4 (zeige HDAC5 ELISA Kits) binds to chromatin as well as to MEF2A (zeige MEF2A ELISA Kits) transcription factor, leading to histone deacetylation and altered neuronal gene expression. By using a Cdkl5 knockout (Cdkl5 -/Y) mouse model, we found that hypophosphorylated HDAC4 (zeige HDAC5 ELISA Kits) translocates to the nucleus of neural precursor cells, thereby reducing histone 3 acetylation.

  4. We have characterised the predominant brain isoform of CDKL5, a 9.7 kb transcript comprised of 18 exons with a large 6.6 kb 3'-untranslated region (UTR (zeige UTS2R ELISA Kits)), which we name hCDKL5_1. In addition we describe new exonic regions and a range of novel splice and UTR (zeige UTS2R ELISA Kits) isoforms

  5. Taken together, these results strongly suggested that DYRK1A (zeige DYRK1A ELISA Kits) bound to CDKL5 and phosphorylated it on Ser (zeige SIGLEC1 ELISA Kits)-308, thus interfering with its nuclear localization.

  6. CDKL5 deletion during development more markedly impairs the establishment of a correct GABAergic cerebellar network than that of glutamatergic one, leading to the behavioural symptoms associated with CDKL5 mutation.

  7. these results point to a role of CDKL5 in the early steps of neuronal differentiation that can be explained, at least in part, by its association with shootin1.

  8. Findings highlight a critical role of CDKL5 in the fundamental processes of brain development, namely neuronal precursor proliferation, survival and maturation

  9. Amph1 (zeige AMPH ELISA Kits) is the cytoplasmic substrate for CDKL5.

  10. CDKL5 regulates signal transduction pathways and mediates autistic-like phenotypes.

CDKL5 Antigen-Profil

Beschreibung des Gens

This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.

Alternative names and synonyms associated with CDKL5

  • cyclin-dependent kinase-like 5 (CDKL5) Elisa Kit
  • cyclin-dependent kinase-like 5 (cdkl5) Elisa Kit
  • cyclin-dependent kinase-like 5 (LOC100355402) Elisa Kit
  • cyclin-dependent kinase-like 5 (Cdkl5) Elisa Kit
  • BC038161 Elisa Kit
  • EIEE2 Elisa Kit
  • ISSX Elisa Kit
  • Stk9 Elisa Kit

Bezeichner auf Proteinebene für CDKL5

cyclin-dependent kinase-like 5 , cyclin-dependent kinase-like 5-like , cyclin dependent kinase 5 transcript , serine/threonine kinase 9 , serine/threonine-protein kinase 9

GENE ID SPEZIES
100057902 Equus caballus
428001 Gallus gallus
100145195 Xenopus (Silurana) tropicalis
100355402 Oryctolagus cuniculus
100407783 Callithrix jacchus
100472831 Ailuropoda melanoleuca
100583908 Nomascus leucogenys
6792 Homo sapiens
382253 Mus musculus
491761 Canis lupus familiaris
100623797 Sus scrofa
538337 Bos taurus
100362725 Rattus norvegicus
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