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Kazrin (zeige KAZ ELISA Kits) interacts with ARVCF (zeige ARVCF ELISA Kits)-catenin, spectrin and p190B RhoGAP (zeige ARHGAP1 ELISA Kits), and modulates RhoA (zeige RHOA ELISA Kits) activity.
only collagen-IV (zeige COL4 ELISA Kits) elicits the formation of proteolytically active podosomes through a mechanism involving increased Src (zeige SRC ELISA Kits) phosphorylation, p190RhoGAP (zeige GRLF1 ELISA Kits)-B (also known as ARHGAP5) relocalisation and MT1-MMP (zeige MMP14 ELISA Kits) (also known as MMP14 (zeige MMP14 ELISA Kits)) cell surface exposure at podosome sites.
Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (zeige CIITA ELISA Kits) (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (zeige ADAMTS9 ELISA Kits) (rs7631391), DOCK2 (zeige DOCK2 ELISA Kits) (rs77594147), SLC28A1 (zeige SLC28A1 ELISA Kits) (rs28649017), ARHGAP5 (rs7151991), and CIITA (zeige CIITA ELISA Kits) (rs45601437) in the Asian comparison.
This newly identified miR (zeige MLXIP ELISA Kits)-744/ARHGAP5 pathway provides further insight into the progression and metastasis of NPC (zeige NPC1 ELISA Kits) and indicates potential novel therapeutic targets for NPC (zeige NPC1 ELISA Kits).
Ectopic expression of p190B suppressed the miR (zeige MLXIP ELISA Kits)-494-induced EGFR (zeige EGFR ELISA Kits) upregulation.
The expression level of miR (zeige MLXIP ELISA Kits)-486-5p was inversely correlated with that of ARHGAP5.
RhoA (zeige RHOA ELISA Kits) is down-regulated at cell-cell contacts via p190RhoGAP (zeige GRLF1 ELISA Kits)-B in response to tensional homeostasis.
Data indicate a role for p120-catenin (amino acids 820-843) domain in the p120-catenin.p190RhoGAP signaling complex assembly and membrane targeting.
A cell cycle-regulated reduction in endogenous p190 (zeige CNTNAP1 ELISA Kits) levels is linked to completion of cytokinesis and generation of viable cell progeny.
precise control of p190-B Rho GTPase-activating protein activity is critical for normal branching morphogenesis during mammary gland development
ARHGAP5 (the gene encoding p190-B RhoGAP (zeige ARHGAP1 ELISA Kits)) is a probable target for the amplification at 14q12, and p190-B RhoGAP (zeige ARHGAP1 ELISA Kits) promotes cells spreading and migration by negatively regulating RhoA (zeige RHOA ELISA Kits) activity in Huh-7 hepatocellular carcinoma cells
Loss of p190-B expression is associated with defective hematopoiesis.
Rac1 activity and oxidative stress are elevated in tumors expressing exogenous p190B suggesting that p190B may promote tumorigenesis through a Rac1/ROS (zeige ROS1 ELISA Kits) dependent mechanism.
p190B haploinsufficiency in the epithelium inhibits MMTV-Neu tumor initiation. p190B deficiency in the vasculature is responsible, in part, for the inhibition of MMTV-Neu tumor progression.
Mice lacking the Rho-inhibitory protein, p190-B RhoGAP (zeige ARHGAP1 ELISA Kits), are 30% reduced in size and exhibit developmental defects strikingly similar to those seen in mice lacking the CREB (zeige CREB1 ELISA Kits) transcription factor.
Results suggest that p190-B regulates ductal morphogenesis, at least in part, by modulating the IGF signaling axis
IGF signaling through p190-B and IRS (zeige IARS ELISA Kits) proteins is critical for mammary bud formation and ensuing epithelial-mesenchymal interactions necessary to sustain mammary bud morphogenesis
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.
Rho GTPase activating protein 5
, chimerin (chimaerin) 1-like
, rho GTPase-activating protein 5-like
, growth factor independent 2
, p100 RasGAP-associated p105 protein
, p105 RhoGAP
, rho GTPase-activating protein 5
, rho-type GTPase-activating protein 5