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this study clearly provided evidence that FilGAP, as well as IDH1 status, may be useful for predicting the behavior of astrocytomas. In addition, the FilGAP/Rac1 axis may serve as an important regulator of tumor progression in GBMs, probably through alteration of cell morphology.
ARHGAP24 may regulate pseudopod formation downstream of activated ARF6 (zeige ARF6 ELISA Kits) in MDA-MB-231 human breast carcinoma cells.
Study identified FilGAP as a negative regulator of lymphocyte polarization and migration and shows that FilGAP may suppress lamellae formation at the front of migrating lymphocyte.
Src (zeige SRC ELISA Kits) family tyrosine kinase (zeige TXK ELISA Kits) signaling may regulate FilGAP through association with RBM10 (zeige RBM10 ELISA Kits)
FilGAP may contribute to change in cell motility of B-lymphocytes and in addition, its expression appears to be useful for predicting the behavior of B-cell lymphoma, in particular follicular lymphoma.
study suggests that Arf6 (zeige ARF6 ELISA Kits) and phosphorylation of FilGAP may regulate FilGAP, and phosphorylation of Ser (zeige SIGLEC1 ELISA Kits)-402 may play a role in the regulation of cell spreading on fibronectin (zeige FN1 ELISA Kits)
Polymorphism rs346473 in the ARHGAP24 gene might be a part of the genetic variants.
FilGAP may function as a mediator of the regulation of Rac (zeige AKT1 ELISA Kits) by Arf6 (zeige ARF6 ELISA Kits).
Data indicate that phosphorylation of FilGAP by ROCK appears to promote amoeboid morphology.
Consistent with structural predictions, strain increases beta-integrin binding to FLNA (zeige FLNA ELISA Kits), whereas it causes FilGAP to dissociate from FLNA (zeige FLNA ELISA Kits), providing a direct and specific molecular basis for cellular mechanotransduction
Absence of TAp73 (zeige TP73 ELISA Kits) leads to activation of TGF-beta (zeige TGFB1 ELISA Kits) signaling through a Sma (zeige ACTA2 ELISA Kits) and Mad-related proteins-independent pathway, favoring oncogenic transforming growth factor-beta effects and epithelial-to-mesenchymal transition.
Findings reinforce the role of TAp73 (zeige TP73 ELISA Kits) as tumor suppressor gene and indicate that the regulation of cellular metabolism by TAp73 (zeige TP73 ELISA Kits) contributes to its tumor suppressor function.
cells expressing both p63 (zeige CKAP4 ELISA Kits) and p73 exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.
both p53 (zeige TP53 ELISA Kits) and p73 are critical in apoptosis induced by DNA damage and differentiation.
New function of p73, independent of p53 (zeige TP53 ELISA Kits), in the neurogenic architecture of the SVZ of rodent brain.
these results therefore highlight an unanticipated role for p53 (zeige TP53 ELISA Kits) family proteins in a regulatory network that integrates essential Wnt (zeige WNT2 ELISA Kits)-Tcf (zeige HNF4A ELISA Kits) and nodal-Smad (zeige SMAD1 ELISA Kits) inputs.
TAp73 (zeige TP73 ELISA Kits) as necessary and sufficient for basal body docking, axonemal extension, and motility during the differentiation of Motile multiciliated cell progenitors.
p73 drives multiciliogenesis, both through transcriptional activation of a master ciliogenesis transcription factor FoxJ1 (zeige FOXJ1 ELISA Kits) and through regulation of multiple genes central to ciliogenesis.
The p73 acts as a critical regulator of multiciliogenesis in its capacity as a sequence-specific transcription factor, through genomic binding and regulation of genes.
Data show that the Mdm4 (zeige MDM4 ELISA Kits)-p73 axis cannot override the dominant role of p53 (zeige TP53 ELISA Kits) in development and tumorigenesis and that Mdm4 (zeige MDM4 ELISA Kits) and p73 interaction during development and tumorigenesis suggests new insight into the role of p53 (zeige TP53 ELISA Kits) family members.
ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA\; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004
RAC1- and CDC42-specific GTPase-activating protein of 72 kDa
, filamin-A-associated RhoGAP
, rho GTPase-activating protein 24
, rho-type GTPase-activating protein 24
, rhoGAP of 73 kDa
, sarcoma antigen NY-SAR-88
, Down-regulated in nephrectomized rat kidney 2
, p53-like transcription factor
, p53-related protein
, tumor protein p73
, transformation related protein 73