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Human APOE Protein expressed in Human - ABIN934462
Krul, Cole: Quantitation of apolipoprotein E. in Methods in enzymology 1996
Human APOE Protein expressed in HEK-293 Cells - ABIN2714829
Pan, Zhou, Mahsut, Rohm, Berejnaia, Price, Chen, Castro-Perez, Lassman, McLaren, Conway, Jensen, Thomas, Reyes-Soffer, Ginsberg, Gutstein, Cleary, Previs, Roddy: Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS. in Journal of lipid research 2016
Report a disturbance in sphingolipid and glycerophospholipid metabolism during the progression of atherosclerotic dyslipidemia in ApoE knockout mice fed high fat diet.
Eight-week-old ApoE-/-mice were fed a western diet while being administered AnxA5 or control (M1234) for a total of 6 weeks. AnxA5 administration reduced plaque size in the aortic root as well as the aortic arch by 36% and 55% respectively
Study is the first showing the significance of APOE in attenuating early brain injury after subarachnoid hemorrhage through a blood-brain barrier modulation-dependent manner.
Tauroursodeoxycholic acid attenuates Ang II (zeige AGT Proteine) induced abdominal aortic aneurysm formation in ApoE(-/-) mice by inhibiting endoplasmic reticulum stress mediated apoptosis.
The combined data indicate that the K146N/R147W substitutions convert the full-length and the truncated apoE3[K146N/R147W] mutant into a dominant negative ligand that prevents receptor-mediated remnant clearance, exacerbates the dyslipidemia, and inhibits the biogenesis of HDL (zeige HSD11B1 Proteine).
The ApoE4 brains showed increased expression of interleukin receptor-associated kinase-1and downregulated by miR146) that correlated inversely with miR146a levels.
Rutaecarpine was identified to be a candidate that protected ApoE(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 (zeige ABCA1 Proteine) and SR-BI (zeige SCARB1 Proteine) within RCT (zeige FOXE3 Proteine).
224 male F2 mice were generated from the two Apoe (-/-) strains to perform quantitative trait locus (QTL) analysis of atherosclerosis. F2 mice were fed 5 weeks of Western diet and analyzed for atherosclerotic lesions in the aortic root
Low dose dietary nitrate improves endothelial dysfunction and plaque stability in the ApoE-deficient mouse fed a high fat diet.
Ovariectomy and ApoE deficiency showed interaction potentializing the insulin (zeige INS Proteine) resistance, increasing triglycerides levels and altering angiotensin-converting enzyme (ACE (zeige ACE Proteine))-2 (zeige ACE2 Proteine) and Mas (zeige MAS1 Proteine) receptor gene expressions.
Study elucidated that the APOE4 epsilon4 allele can enhance AD susceptibility and promotes the expressions of inflammatory factors in Alzheimer's disease (AD). Additionally, the epsilon3/4 genotype and TNF-alpha (zeige TNF Proteine), IL-6 (zeige IL6 Proteine), and IL-1beta (zeige IL1B Proteine) levels were associated with AD susceptibility in the Han population, while the epsilon3/4 and epsilon4/4 genotypes and TNF-alpha (zeige TNF Proteine), IL-6 (zeige IL6 Proteine), and IL-1beta (zeige IL1B Proteine) levels were associated with AD susceptibi...
The data of this study question the relevance of the APOE-epsilon4 allele as a predictor of cognitive impairment in PD.
this study shows protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer's disease
Report altered hippocampal functional connectivity in carriers with risk APOE epsilon4 or SORL1 (zeige SORL1 Proteine) G-allele, which may predispose these risk-allele carriers to be susceptible for Alzheimer disease.
This study demonstrated that Young adult APOE4 carriers displayed upregulation of specific glucose (GLUT1 (zeige SLC2A1 Proteine) & GLUT3 (zeige SLC2A3 Proteine)) and monocarboxylate (MCT2) transporters, the glucose metabolism enzyme hexokinase, the SCOT (zeige OXCT1 Proteine) & AACS (zeige AACS Proteine) enzymes involved in ketone metabolism, and complexes I, II, and IV of the mitochondrial electron transport chain.
RNA interference of transcriptional factor activator protein 2alpha (AP-2alpha (zeige TFAP2A Proteine)) reversed the inhibitory effects of aspirin on atherosclerosis in Apoe-/- mice.
Alzheimer's disease was associated with decreased selenium concentration in both soluble (i.e., cytosolic) and insoluble (i.e., plaques and tangles) fractions of brain homogenates. The presence of the APOE epsilon4 allele correlated with lower total selenium levels in the temporal cortex and a higher concentration of soluble selenium.
Results show that apoE4-driven brain pathology and cognitive impairments in young apoE4 TR mice are associated with down regulation of the VEGF system and can be reversed by upregulation of the expression of VEGF in the hippocampus. These animal model findings suggest that the VEGF system is a promising target for the treatment of apoE4 carriers in Alzheimers disease.
The Logistic regression and Bonferroni correction in a subgroup of the cohort adjusted for gender, age, and population maintained the association of APOE rs429358 and varepsilon4 allele.
Apolipoprotein E epsilon 4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV-infected individuals.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (zeige APOA1 Proteine) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (zeige HSD11B1 Proteine) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (zeige APOB Proteine), ApoE, MTP (zeige MTTP Proteine), and LDLR (zeige LDLR Proteine), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (zeige HSD11B1 Proteine) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (zeige APOB Proteine)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (zeige MTTP Proteine)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3