anti-GRB10 (GRB10) Antikörper

Bezeichnung:
anti-Growth Factor Receptor-Bound Protein 10 Antikörper (GRB10)
Auf www.antikoerper-online.de finden Sie aktuell 89 Growth Factor Receptor-Bound Protein 10 (GRB10) Antikörper von 22 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen GRB10 Kits (36) und GRB10 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 141 GRB10 Produkte verfügbar.
Synonyme:
5730571D09Rik, AI325020, Grb-10, GRB-IR, GRB10, IRBP, LOC100224775, MEG1, mKIAA0207, RGD1566234, RSS, zgc:91987
Alle Antikörper anzeigen Gen GeneID UniProt
GRB10 14783 Q60760
GRB10 498416  
GRB10 2887 Q13322

Alle Spezies anzeigen

Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-GRB10 (GRB10) Antikörper

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anti-Mouse (Murine) GRB10 Antikörper:

anti-Rat (Rattus) GRB10 Antikörper:

anti-Human GRB10 Antikörper:

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Am meisten referenzierte anti-GRB10 Antikörper

  1. Human Polyclonal GRB10 Primary Antibody für WB - ABIN1881389 : ONeill, Rose, Pillay, Hotta, Olefsky, Gustafson: Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. in The Journal of biological chemistry 1996 (PubMed)
    Zeige alle 5 Referenzen für 1881389

  2. Human Polyclonal GRB10 Primary Antibody für IF, ELISA - ABIN1531649 : Angrist, Bolk, Bentley, Nallasamy, Halushka, Chakravarti: Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease. in Oncogene 1999 (PubMed)

Weitere Antikörper gegen GRB10 Interaktionspartner

Mouse (Murine) Growth Factor Receptor-Bound Protein 10 (GRB10) Interaktionspartner

  1. In tumors, Grb10 loss independently promotes Ras pathway hyperactivation, which promotes hyperproliferation, an early feature of tumor development.

  2. This study identified Grb10 as a critical regulator of lipid metabolism, the programming of the browning phenotype, and thermogenesis in adipose tissues.

  3. Negative regulation of Grb10 Interacting GIGYF2 (zeige GIGYF2 Antikörper) protein on IGF-1 (zeige IGF1 Antikörper) receptor signaling pathway caused diabetic mice cognitive impairment.

  4. Grb10 is involved in BCR-ABL (zeige ABL1 Antikörper)-positive leukemia in mice.

  5. Grb10 is a key genetic component of developmental programming.

  6. Glucose uptake was higher in Grb10(-/-) primary myotubes in the basal state and was associated with enhanced insulin (zeige INS Antikörper) signaling and an increase in GLUT4 (zeige SLC2A4 Antikörper) translocation to the plasma membrane.

  7. Grb10 expression in mouse embryo is regulated by Lmx1a (zeige LMX1A Antikörper) transcription factor.

  8. Results suggest consecutive passaging may affect epigenetic modifications of Grb10 in adult fibroblast cells.

  9. Study has identified Grb10 as an important regulator of beta-cell proliferation and demonstrated that reducing the expression level of Grb10 could provide a novel means to increase beta-cell mass and reduce beta-cell apoptosis.

  10. Grb10-ablated muscle from adult mice shows coordinate gene changes that oppose those of muscle wasting pathologies, highlighting Grb10 as a potential therapeutic target for these conditions

Human Growth Factor Receptor-Bound Protein 10 (GRB10) Interaktionspartner

  1. Data suggest that GRB10 and GRB14 (zeige GRB14 Antikörper) are both Ca2 (zeige CA2 Antikörper)+-dependent CaM (zeige CALM1 Antikörper)-binding proteins; more than one CaM (zeige CALM1 Antikörper)-binding site and/or accessory CaM (zeige CALM1 Antikörper)-binding sites appear to exist in GRB10 and GRB14 (zeige GRB14 Antikörper), as compared to a single one present in GRB7 (zeige GRB7 Antikörper). (GRB10 = growth factor receptor-bound protein 10; GRB14 (zeige GRB14 Antikörper) = growth factor receptor-bound protein 14 (zeige GRB14 Antikörper); CaM (zeige CALM1 Antikörper) = calmodulin (zeige CALM1 Antikörper); GRB7 (zeige GRB7 Antikörper) = growth factor receptor-bound protein 7 (zeige GRB7 Antikörper))

  2. GRB10 may regulate degradation of the IL-4 (zeige IL4 Antikörper) receptor-signaling complex through interactions with NEDD4.2 (zeige NEDD4L Antikörper).

  3. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (zeige ADCY5 Antikörper), ADRA2A (zeige ADRA2A Antikörper), CDKAL1 (zeige CDKAL1 Antikörper), CDKN2A (zeige CDKN2A Antikörper)/B, GRB10, and TCF7L2 (zeige TCF7L2 Antikörper)

  4. This study demonstrated that the most significant SNP (rs11770199; p = 0.0003) in single-site analysis was located on chromosome 7 in the GRB10 gene.

  5. Association of the intronic polymorphism rs12540874 A>G of the GRB10 gene with high birth weight.

  6. Tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism.

  7. Grb10 binds to both normal and oncogenic FLT3 (zeige FLT3 Antikörper) and induces PI3K (zeige PIK3CA Antikörper)-Akt (zeige AKT1 Antikörper) and STAT5 (zeige STAT5A Antikörper) signaling pathways resulting in an enhanced proliferation, survival and colony formation of hematopoietic cells.

  8. Studies indicate that insulin receptor (IR (zeige INSR Antikörper)) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10/14 and SH2B1 (zeige SH2B1 Antikörper)/B2 adaptors.

  9. H19 (zeige NCKAP1 Antikörper) and GRB10 methylation was normal in Albright's hereditary osteodystrophy patients.

  10. discovery of Grb10 as an mTORC1 substrate

GRB10 Antigen-Profil

Beschreibung des Gens

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with GRB10

  • growth factor receptor-bound protein 10 (GRB10) Antikörper
  • growth factor receptor-bound protein 10a (grb10a) Antikörper
  • growth factor receptor-bound protein 10 (grb10) Antikörper
  • growth factor receptor-bound protein 10 (LOC100224775) Antikörper
  • growth factor receptor bound protein 10 (Grb10) Antikörper
  • growth factor receptor-bound protein 10 (Grb10) Antikörper
  • growth factor receptor-bound protein 10-like (LOC100355737) Antikörper
  • 5730571D09Rik Antikörper
  • AI325020 Antikörper
  • Grb-10 Antikörper
  • GRB-IR Antikörper
  • GRB10 Antikörper
  • IRBP Antikörper
  • LOC100224775 Antikörper
  • MEG1 Antikörper
  • mKIAA0207 Antikörper
  • RGD1566234 Antikörper
  • RSS Antikörper
  • zgc:91987 Antikörper

Bezeichner auf Proteinebene für GRB10

growth factor receptor-bound protein 10 , zgc:91987growth factor receptor-bound protein 10 , growth factor receptor-bound protein 10-like , GRB10 adapter protein , maternally expressed gene 1 protein , GRB10 adaptor protein , insulin receptor-binding protein Grb-IR , maternally expressed gene 1 , adapter protein , binds to insulin receptor and IGF1R

GENE ID SPEZIES
100052610 Equus caballus
446167 Danio rerio
463410 Pan troglodytes
694786 Macaca mulatta
100151701 Xenopus (Silurana) tropicalis
100224775 Taeniopygia guttata
100381089 Xenopus laevis
100402854 Callithrix jacchus
100434903 Pongo abelii
100476882 Ailuropoda melanoleuca
100542734 Meleagris gallopavo
100564990 Anolis carolinensis
100599409 Nomascus leucogenys
14783 Mus musculus
498416 Rattus norvegicus
2887 Homo sapiens
607755 Canis lupus familiaris
100188977 Sus scrofa
407210 Bos taurus
100733471 Cavia porcellus
420948 Gallus gallus
101111275 Ovis aries
100355737 Oryctolagus cuniculus
Ausgewählte Anbieter für anti-GRB10 (GRB10) Antikörper
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