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A significant decrease in DUSP12 expression in hypertrophic hearts and cardiomyocytes.
These results propagate a role for dual specificity phosphatases at RNP (zeige RNPC3 ELISA Kits) particles and suggest that hYVH1 may affect a variety of fundamental cellular processes by regulating messenger ribonucleoprotein (zeige RBP31 ELISA Kits) (mRNP) dynamics.
propose that the BRC repeats in BRCA2 (zeige BRCA2 ELISA Kits) cooperate in a partially redundant but reinforcing manner to ensure a high probability of RAD51 (zeige RAD51 ELISA Kits) filament formation
these data suggests common SNPs within DUSP12-ATF6 (zeige ATF6 ELISA Kits) locus may not play a major role in glucose metabolism in the Chinese.
tudies confirmed elevated expression of three target antigens RAB38, TBCE, and DUSP12 in CML.
Our data suggest that sequences in or upstream of DUSP12 may contribute to type 2 diabetes susceptibility, but the lack of replication suggests a small effect size.
hYVH1 is a novel cell survival phosphatase that co-operates with Hsp70 (zeige HSP70 ELISA Kits) to positively affect cell viability in response to cellular insults.
The regulatory role of DUSP12 is primarily through c-Jun N-terminal kinase (JNK) inhibition.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.
dual specificity phosphatase 12
, dual specificity protein phosphatase 12
, Dual specificity protein phosphatase 12
, dual specificity protein phosphatase 12-like
, YVH1 protein-tyrosine phosphatase ortholog
, dual specificity tyrosine phosphatase YVH1
, serine/threonine specific protein phosphatase
, dual specificity phosphatase T-DSP4
, dual specificity phosphatase VH1
, glucokinase-associated dual specificity phosphatase