anti-Human Slit Homolog 2 (Drosophila) Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended Slit Homolog 2 (Drosophila) Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Slit Homolog 2 (Drosophila) (SLIT2) Antikörper
  • SLIL3
  • Slit-2
  • Drad-1
  • E030015M03Rik
  • E130320P19Rik
  • Slil3
  • mKIAA4141
  • Slit
  • slil3
  • slit-2
  • slit2-a
  • SLIT2
  • slit homolog 2 (Drosophila)
  • slit (Drosophila) homolog 2
  • slit homolog 2
  • SLIT2
  • Slit2
  • slit2
Reaktivität
Human, Maus, Ratte (Rattus)
99
67
35
3
3
2
2
1
1
1
1
1
Wirt
Kaninchen
68
26
17
3
2
Klonalität
Polyklonal
Konjugat
Unkonjugiert
9
6
4
4
4
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
46
39
38
29
24
12
6
5
5
2
2
1
Optionen
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Bilder

Produktnummer ABIN749963
$ 307.45
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2806463 IF (p) Alexa Fluor 594 Rabbit IgG AA 470-520 Anmelden zum Anzeigen Polyclonal
1 ABIN749966 IF (p) Cy3 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN749968 IF (p) Cy5.5 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN749967 IF (p) Cy5 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN749969 IF (p) Cy7 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN749970 IF (p) FITC Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN915627 IF (p) Alexa Fluor 555 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN915628 IF (p) Alexa Fluor 350 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN915630 IF (p) Alexa Fluor 647 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN915629 IF (p) Alexa Fluor 488 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN5010685 IF (p) Alexa Fluor 750 Rabbit IgG AA 470-520 Anmelden zum Anzeigen Polyclonal
1 ABIN5010684 IF (p) Alexa Fluor 680 Rabbit IgG AA 470-520 Anmelden zum Anzeigen Polyclonal

General

Antigen Slit Homolog 2 (Drosophila) (SLIT2) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(99), (67), (35), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Wirt Kaninchen
(68), (26), (17), (3), (2)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(9), (6), (4), (4), (4), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(46), (39), (38), (29), (24), (12), (6), (5), (5), (2), (2), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Slit2
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Slit2/Slil3 (SLIT2 Antibody Abstract)
Hintergrund

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.

Subcellular location: Secreted

Synonyms: SLIL3, Slit-2, Slit homolog 2 protein, SLIT2

Gen-ID 9353
UniProt O94813
Pathways Regulation of Actin Filament Polymerization, Regulation of Cell Size, Smooth Muscle Cell Migration

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Bilder zurück nach oben
Applikationshinweise IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Slit Homolog 2 (Drosophila) (SLIT2) antibody (ABIN749963) Formalin-fixed and paraffin embedded rat brain labeled with Anti-Slit2/Slil3 Polyclon...