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SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
describe the identification of the structural determinants responsible for the CA IX (zeige CA9 ELISA Kits)/CAND1 interaction
Data show that the differentiation of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1), COP9 (zeige COPS8 ELISA Kits) signalosome (CSN), neddylated cullin 3 (Cul3 (zeige CUL3 ELISA Kits)) and the BTB protein Keap1 (zeige KEAP1 ELISA Kits).
The Epstein-Barr virus protein BPLF1, is targeted to cullin-RING ubiquitin ligases (CRLs) via the interaction of the conserved helix-2 with helix-23 of cullins, at a site involved in electrostatic interaction with CAND1.
We demonstrate that the accumulation of p27 (zeige PAK2 ELISA Kits) is associated with an increase of CAND1 and a decrease of Skp2 during adipogenesis of human LiSa-2 preadipocytes. CAND1 knockdown reduces p27 (zeige PAK2 ELISA Kits) and blocks adipogenesis.
Study shows that Cand1 can unambiguously stimulate SCF (zeige KITLG ELISA Kits) activity in vitro by enabling an F box protein (zeige FBXW10 ELISA Kits)-Skp1 (zeige SKP1 ELISA Kits) complex to access Cul1 (zeige CUL1 ELISA Kits) that was previously occupied by a different F box protein (zeige FBXW10 ELISA Kits)-Skp1 (zeige SKP1 ELISA Kits) complex, and that Cand1 promotes assembly in vivo of new F box proteins with pre-existing Cul1 (zeige CUL1 ELISA Kits) molecules.
CAND1 promotes PLK4 (zeige PLK4 ELISA Kits)-mediated centriole overduplication and is frequently disrupted in prostate cancer.
COMMD1 (zeige COMMD1 ELISA Kits) (copper metabolism MURR1 (zeige COMMD1 ELISA Kits) domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
CAND1 does not function by sequestering cullins in vivo to prevent substrate receptor autoubiquitination and is likely to regulate cullin RING ligase activity via alternative mechanisms
miR (zeige MLXIP ELISA Kits)-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression.
selectively binds to unneddylated CUL1 (zeige CUL1 ELISA Kits) and is dissociated by CUL1 (zeige CUL1 ELISA Kits) neddylation
HVE/CAND1 gene acts upstream of ATHB-8 at least in higher order veins, in a pathway that involves AXR1, but not LOP1, PIN1, CVP1 or CVP2.
The disruption of the CAND1-CUL1 interaction results in an increased abundance of assembled SCF(TIR1) complex; stabilization of the CAND1-CUL1 interaction diminishes SCF(TIR1) complex abundance.
Enhances transcription from various types of promoters. Regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. Prevents neddylation of CUL1 by physically blocking access to the neddylation site. Disrupts interactions between CUL1 and SKP1 and between CUL1 and F-box proteins (By similarity).
TBP interacting protein
, TBP-interacting protein 120A
, TBP-interacting protein of 120 kDa A
, cullin-associated NEDD8-dissociated protein 1
, cullin-associated and neddylation-dissociated protein 1
, p120 CAND1
, TBP-interacting protein TIP120A
, cullin associated and neddylation disassociated 1
, cullin-associated and neddylation-dissociated 1
, TIP120 protein
, cullin-associated NEDD8-dissociated protein 1-like
, cullin-associated and neddylation-dissociated 2 (putative)
, TBP-interacting protein