anti-Maus CAND1 Antikörper für Immunoprecipitation

Recommended CAND1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Cullin-Associated and Neddylation-Dissociated 1 (CAND1) Antikörper
  • cand2
  • tip120
  • tip120a
  • 2310038O07Rik
  • 6330512O03Rik
  • AI195005
  • AI846556
  • D10Ertd516e
  • Tp120a
  • mKIAA0829
  • TIP120
  • TIP120A
  • Tip120
  • Tip120A
  • fb78a05
  • wu:fb78a05
  • zgc:55729
  • ATCAND1
  • CULLIN-ASSOCIATED AND NEDDYLATION DISSOCIATED 1
  • ETA2
  • HEMIVENATA
  • HVE
  • T8K22.14
  • T8K22_14
  • cullin-associated and neddylation dissociated
  • cullin-associated and neddylation-dissociated 1
  • cullin associated and neddylation disassociated 1
  • cullin-associated NEDD8-dissociated protein 1
  • CAND1
  • cand1
  • Cand1
Epitop
N-Term, AA 11-24
10
6
6
5
4
3
2
2
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
45
15
12
7
6
6
5
5
5
3
3
3
2
2
2
Wirt
Kaninchen
32
13
Klonalität
Polyklonal
Applikation
Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
42
20
15
15
13
10
4
2
1
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN117944
$ 419.10
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN117945 EIA IP WB Rabbit C-Term, AA 1130-1143 Anmelden zum Anzeigen Polyclonal 9
1 ABIN4359842 ICC IF IHC IHC (p) IP WB Rabbit AA 1180-1230 Anmelden zum Anzeigen Polyclonal
1 ABIN303072 EIA IHC (p) IP WB Rabbit N-Term Anmelden zum Anzeigen Polyclonal
1 ABIN604593 IP ELISA WB Rabbit AA 11-24 Anmelden zum Anzeigen Polyclonal
1 ABIN1732591 IHC (p) IP ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN4359841 ELISA IHC IHC (p) IP WB Rabbit Anmelden zum Anzeigen Polyclonal
1 ABIN2629240 IF IHC (p) IP WB Rabbit IgG AA 1180-1230 Anmelden zum Anzeigen Polyclonal
1 ABIN1941959 IP Rabbit IgG AA 600-650 Anmelden zum Anzeigen Polyclonal

General

Antigen Cullin-Associated and Neddylation-Dissociated 1 (CAND1) Antikörper
Epitop N-Term, AA 11-24
(10), (6), (6), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(45), (15), (12), (7), (6), (6), (5), (5), (5), (3), (3), (3), (2), (2), (2)
Wirt Kaninchen
(32), (13)
Klonalität
Polyklonal
Applikation Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
(42), (20), (15), (15), (13), (10), (4), (2), (1)
Pubmed 9 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-CAND1 Antikörper

Target Details CAND1 Anwendungsinformationen Handhabung Referenzen für anti-CAND1 Antikörper (ABIN117944) Bilder
Sequenz Human CAND1 (TIP120A) (1230 aa 136.4 kDa): 1 masasyhisn llekmtssdk dfrfmatndl mtelqkdsik ldddserkvv kmilklledk 61 ngevqnlavk clgplvskvk eyqvetivdt lctnmlsdke qlrdissigl ktvigelppa 121 ssgsalaanv ckkitgrlts aiakqedvsv qlealdimad mlsrqggllv nfhpsiltcl 181 lpqltsprla vrkrtiialg hlvmscgniv fvdliehlls elskndsmst trtyiqciaa 241 isrqaghrig eylekiiplv vkfcnvddde lreyciqafe sfvrrcpkev yphvstiini -- 901 sqpkrqylll hslkeiissa svvglkpyve niwalllkhc ecaeegtrnv vaeclgkltl 961 idpetllprl kgylisgssy arssvvtavk ftisdhpqpi dpllkncigd flktledpdl 1021 nvrrvalvtf nsaahnkpsl irdlldtvlp hlynetkvrk elirevemgp fkhtvddgld 1081 irkaafecmy tlldscldrl difeflnhve dglkdhydik mltflmlvrl stlcpsavlq 1141 rldrlveplr atcttkvkan svkqefekqd elkrsamrav aalltipeae ksplmsefqs 1201 qissnpelaa ifesiqkdss stnlesmdts
Spezifität This product is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. This antibody reacts with human, rat and mouse CAND1/TIP120A. Cross reactivity does occur with human, rat and mouse CAND2/TIP120B. Cross reactivity with CAND1 from other sources is not known.
Reinigung Delipidation and defibrination.
Immunogen This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 11-24 of Human CAND1/TIP120A (N- terminal) coupled to KLH.

Target Details CAND1

Produktdetails anti-CAND1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-CAND1 Antikörper (ABIN117944) Bilder zurück nach oben
Antigen
Andere Bezeichnung CAND1 (CAND1 Antibody Abstract)
Hintergrund CAND1 is also known as TIP120A, and TATA-binding protein-interacting protein 120A. The SCF complex consists of the invariable components Skp1, Cul1, and Rbx1 as well as a variable F-box protein, and functions as an E3 ubiquitin ligase. E3 ubiquitin ligases regulate various physiological processes. CAND1 binds to Cul1 and potentially regulates the SCF complex. CAND1 physically associates with Cul1 in the nucleus and this interaction is mediated by a central region of Cul1 distinct from its binding sites for Skp1 and Rbx1. CAND1 selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation. CAND1 forms a ternary complex with CUL1 and ROC1.Synonyms: Cullin-associated NEDD8-dissociated protein 1, Cullin-associated and neddylation-dissociated protein 1, KIAA0829, TBP-interacting protein TIP120A, TBP-interacting protein of 120 kDa A, TIP120, TIP120A, p120 CAND1
Gen-ID 55832
NCBI Accession NP_060918
UniProt Q86VP6
Forschungsgebiet Apoptosis/Necrosis, Proteasome
Pathways Regulation of Actin Filament Polymerization

Anwendungsinformationen

Produktdetails anti-CAND1 Antikörper Target Details CAND1 Handhabung Referenzen für anti-CAND1 Antikörper (ABIN117944) Bilder zurück nach oben
Applikationshinweise Western blot (1: 500-1: 1,000). Immunoprecipitation: The antibody immunoprecipitates in vitro translated protein andprotein from cell lysates (using HeLa and NIH-3T3, and others). Coimmunoprecipitation of
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CAND1 Antikörper Target Details CAND1 Anwendungsinformationen Referenzen für anti-CAND1 Antikörper (ABIN117944) Bilder zurück nach oben
Format Liquid
Konzentration 85 mg/mL (by Refractometry)
Handhabung Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-CAND1 Antikörper (ABIN117944)

Produktdetails anti-CAND1 Antikörper Target Details CAND1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Concejero, Chen, Wang, Wang, Lin, Liu, Yang, Yong, Lin, Jawan, Huang, Cheng, Eng: "Living donor liver transplantation for hepatocellular carcinoma: a single-center experience in Taiwan." in: Transplantation, Vol. 85, Issue 3, pp. 398-406, 2008

Kim, Min, Lee, Kim, Oh, Jeon, Lee, Im, Chung, Kim, Kim, Bang, Sung, Kim, Heo: "High tumour islet macrophage infiltration correlates with improved patient survival but not with EGFR mutations, gene copy number or protein expression in resected nonsmall cell lung cancer." in: British journal of cancer, 2008

Allgemeine Veröffentlichungen

Min, Hwang, Lee, Park, Tamura, Yoon: "TIP120A associates with cullins and modulates ubiquitin ligase activity." in: The Journal of biological chemistry, Vol. 278, Issue 18, pp. 15905-10, 2003

Oshikawa, Matsumoto, Yada, Kamura, Hatakeyama, Nakayama: "Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1." in: Biochemical and biophysical research communications, Vol. 303, Issue 4, pp. 1209-16, 2003

Zheng, Yang, Harrell, Ryzhikov, Shim, Lykke-Andersen, Wei, Sun, Kobayashi, Zhang: "CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex." in: Molecular cell, Vol. 10, Issue 6, pp. 1519-26, 2002

Liu, Furukawa, Matsumoto, Xiong: "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases." in: Molecular cell, Vol. 10, Issue 6, pp. 1511-8, 2002

Makino, Yogosawa, Kayukawa, Coin, Egly, Wang, Roeder, Yamamoto, Muramatsu, Tamura: "TATA-Binding protein-interacting protein 120, TIP120, stimulates three classes of eukaryotic transcription via a unique mechanism." in: Molecular and cellular biology, Vol. 19, Issue 12, pp. 7951-60, 2000

Jentsch, Pyrowolakis: "Ubiquitin and its kin: how close are the family ties?" in: Trends in cell biology, Vol. 10, Issue 8, pp. 335-42, 2000

Makino, Yoshida, Yogosawa, Tanaka, Muramatsu, Tamura: "Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 4, Issue 9, pp. 529-39, 1999

Bilder

Produktdetails anti-CAND1 Antikörper Target Details CAND1 Anwendungsinformationen Handhabung Referenzen für anti-CAND1 Antikörper (ABIN117944) zurück nach oben
Bilder des Herstellers
 image for anti-Cullin-Associated and Neddylation-Dissociated 1 (CAND1) (AA 11-24), (N-Term) antibody (ABIN117944) Conjugation pathways for ubiquitin and ubiquitin-like modifiers (UBLs). Most modifier...