Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic (CMPK1) (AA 1-228) protein (His tag)
Kurzübersicht für Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic (CMPK1) (AA 1-228) protein (His tag) (ABIN667894)
Target
Alle Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic (CMPK1) Proteine anzeigenProtein-Typ
Spezies
Quelle
Applikation
Reinheit
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Proteineigenschaft
- AA 1-228
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Aufreinigungstag / Konjugat
- His tag
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Sequenz
- MLSRCRSGLL HVLGLSFLLQ TRRPILLCSP RLMKPLVVFV LGGPGAGKGT QCARIVEKYG YTHLSAGELL RDERKNPDSQ YGELIEKYIK EGKIVPVEIT ISLLKREMDQ TMAANAQKNK FLIDGFPRNQ DNLQGWNKTM DGKADVSFVL FFDCNNEICI ERCLERGKSS GRSDDNRESL EKRIQTYLQS TKPIIDLYEE MGKVKKIDAS KSVDEVFDEV VQIFDKEG
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Produktmerkmale
- CMPK1, 1-228aa, Human, His tag, E.coli
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Aufreinigung
- > 90% by SDS-PAGE
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- 20 mM Tris-HCl buffer ( pH 8.0) containing 20 % glycerol, 1 mM DTT, 100 mM NaCl
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Handhabung
- Avoid repeated freezing and thawing cycles
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Lagerung
- 4 °C,-20 °C,-80 °C
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Informationen zur Lagerung
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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- Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic (CMPK1)
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Andere Bezeichnung
- CMPK1
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Hintergrund
- CMPK1, also known as uMP-CMP kinase and deoxycytidylate kinase, is an enzyme that catalyzes the phosphoryl transfer from ATP to uMP, CMP and dCMP. This enzymatic reaction leads to the formation of ADP and the corresponding nucleoside diphosphate, which are required for cellular nucleic acid synthesis. It also plays an important role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. Recombinant human CMPK1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
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Molekulargewicht
- 28.0 kDa (248aa) confirmed by MALDI-TOF
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NCBI Accession
- NP_057392
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Pathways
- Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process
Target
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