Oncostatin M (OSM) (AA 26-234) protein (His tag)

Details zu Produkt Nr. ABIN667495, Anbieter: Anmelden zum Anzeigen
Proteinname
  • OSM
  • OncoM
  • oncostatin M
  • oncostatin M-like
  • oncostatin-M-like
  • OSM
  • Osm
  • LOC100342491
  • LOC100152038
Proteineigenschaft
AA 26-234
7
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Spezies
Human
59
9
5
1
Quelle
Escherichia coli (E. coli)
48
6
3
3
1
1
1
1
1
Protein-Typ
Recombinant
Aufreinigungstag / Konjugat
Dieses Oncostatin M Protein ist gelabelt mit His tag.
Applikation
SDS-PAGE (SDS)
Optionen
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Produktmerkmale OSM, 26-234aa, Human, His tag, E.coli
Reinheit > 95 % by SDS - PAGE
Hintergrund OSM, also known as Oncostatin M, is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction. OSM signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR. Recombinant human OSM protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Oncostatin M, MGC20461, Oncostatin M precursor. NCBI no.: NP_065391
Molekulargewicht 25.9 kDa (230aa), confirmed by MALDI-TOF
Pathways JAK-STAT Signalweg, Negative Regulation of Hormone Secretion
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/ml (determined by Bradford assay)
Buffer Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT
Lagerung 4 °C
Bilder des Herstellers
SDS-PAGE (SDS) image for Oncostatin M (OSM) (AA 26-234) protein (His tag) (ABIN667495) Oncostatin M (OSM) (AA 26-234) protein (His tag)
Allgemeine Veröffentlichungen Nair, DeVico, Nakamura, Copeland, Chen, Patel, ONeil, Oroszlan, Gallo, Sarngadharan: "Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M." in: Science (New York, N.Y.), Vol. 255, Issue 5050, pp. 1430-2, 1992 (PubMed).

Miles, Martínez-Maza, Rezai, Magpantay, Kishimoto, Nakamura, Radka, Linsley: "Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells." in: Science (New York, N.Y.), Vol. 255, Issue 5050, pp. 1432-4, 1992 (PubMed).