60S ribosomal protein L5 protein (GST)

Name: 60S ribosomal protein L5

Protein-Typ: Recombinant

Herkunft (Gen): Human

Konjugat: GST

Applikation: SDS-PAGE (SDS), ELISA, Western Blot (WB)

Zertifikate: ISO 9001:2008

Produktnummer: ABIN618787

Produktbeschreibung

Gen-ID: NM_000969

Sequenz: GFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDK NKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAH ELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEG QVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFG ALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMG QNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYK KAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVA QKKASFLRAQERAAES

Beschreibung: Background: Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA. Defects in RPL5 are the cause of Diamond-Blackfan anemia type 6 (DBA6) [MIM:612561]. DBA6 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.

Molekulargewicht: 34 KD

Anwendungen

Reinheit: 95%

Buffer: 6M guanidine hydrochloride, 20mM Tris

Lagerung: Store at -20 C, for extended storage, conserve at -20 C or -80 C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 C for up to one week.

Beschränkungen: Nur für Forschungszwecke einsetzbar