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TIGIT Protein (partial) (Fc Tag)

TIGIT Spezies: Kaninchen Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. WB, ELISA Active
Produktnummer ABIN5608471
  • Target Alle TIGIT Proteine anzeigen
    TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    partial
    Spezies
    • 18
    • 14
    • 8
    • 6
    • 4
    • 1
    • 1
    Kaninchen
    Quelle
    • 31
    • 7
    • 5
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses TIGIT Protein ist gelabelt mit Fc Tag.
    Applikation
    Western Blotting (WB), ELISA
    Sequenz
    Ala 16 - Pro 142
    Reinheit
    >95 % as determined by SDS-PAGE.
    Endotoxin-Niveau
    Endotoxin level is less than 1.0 EU per ug by the LAL method.
    Biological Activity Comment

    Measured by its binding ability in a functional ELISA. Immobilized Human Nectin-2, His Tag at 5 μg/mL (100 uL/well) can bind Rabbit TIGIT, Fc Tag with a linear range of 5-78 ng/mL (QC tested).

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    Discover our top product TIGIT Protein
  • Applikationshinweise
    This recombinant protein can be used for E, WB.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 100 mM Glycine, pH 7.5
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
  • Target
    TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
    Andere Bezeichnung
    TIGIT (TIGIT Produkte)
    Synonyme
    VSIG9 Protein, VSTM3 Protein, WUCAM Protein, ENSMUSG00000071552 Protein, Vstm3 Protein, RGD1563191 Protein, T-cell immunoreceptor with Ig and ITIM domains Protein, T cell immunoreceptor with Ig and ITIM domains Protein, TIGIT Protein, Tigit Protein
    Hintergrund
    T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
    Molekulargewicht
    40.4 kDa
    Gen-ID
    100343230
    UniProt
    G1SLC1
    Pathways
    Cancer Immune Checkpoints
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