TIGIT Protein (partial) (Fc Tag)
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- Target Alle TIGIT Proteine anzeigen
- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- partial
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Spezies
- Kaninchen
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses TIGIT Protein ist gelabelt mit Fc Tag.
- Applikation
- Western Blotting (WB), ELISA
- Sequenz
- Ala 16 - Pro 142
- Reinheit
- >95 % as determined by SDS-PAGE.
- Endotoxin-Niveau
- Endotoxin level is less than 1.0 EU per ug by the LAL method.
- Biological Activity Comment
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Measured by its binding ability in a functional ELISA. Immobilized Human Nectin-2, His Tag at 5 μg/mL (100 uL/well) can bind Rabbit TIGIT, Fc Tag with a linear range of 5-78 ng/mL (QC tested).
- Top Product
- Discover our top product TIGIT Protein
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- Applikationshinweise
- This recombinant protein can be used for E, WB.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM Glycine, pH 7.5
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
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- Target
- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
- Andere Bezeichnung
- TIGIT (TIGIT Produkte)
- Synonyme
- VSIG9 Protein, VSTM3 Protein, WUCAM Protein, ENSMUSG00000071552 Protein, Vstm3 Protein, RGD1563191 Protein, T-cell immunoreceptor with Ig and ITIM domains Protein, T cell immunoreceptor with Ig and ITIM domains Protein, TIGIT Protein, Tigit Protein
- Hintergrund
- T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
- Molekulargewicht
- 40.4 kDa
- Gen-ID
- 100343230
- UniProt
- G1SLC1
- Pathways
- Cancer Immune Checkpoints
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