MMP13 Protein (AA 105-472) (His tag)

Produktnummer ABIN4976782

Produktdetails

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Protein-Typ: Recombinant

Proteineigenschaft: AA 105-472

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses MMP13 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: YNVFPRTLKW SQTNLTYRIV NYTPDMSHSE VEKAFRKAFK VWSDVTPLNF TRIYDGTADI MISFGTKEHG DFYPFDGPSG LLAHAFPPGP NYGGDAHFDD DETWTSSSKG YNLFIVAAHE LGHSLGLDHS KDPGALMFPI YTYTGKSHFM LPDDDVQGIQ FLYGPGDEDP NPKHPKTPEK CDPALSLDAI TSLRGETMIF KDRFFWRLHP QQVEAELFLT KSFWPELPNH VDAAYEHPSR DLMFIFRGRK FWALNGYDIL EGYPRKISDL GFPKEVKRLS AAVHFENTGK TLFFSENHVW SYDDVNQTMD KDYPRLIEEE FPGIGNKVDA VYEKNGYIYF FNGPIQFEYS IWSNRIVRVM PTNSILWC

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Andere Bezeichnung: MMP13 (MMP13 Produkte)

Synonyme: CLG3 Protein, MANDP1 Protein, Clg Protein, MMP-13 Protein, Mmp1 Protein, cb1034 Protein, mmp13 Protein, gene A Protein, xCol Protein, xcl3 Protein, MMP13 Protein, MGC108008 Protein, matrix metallopeptidase 13 Protein, matrix metallopeptidase 13a Protein, matrix metallopeptidase 13 (collagenase 3) like S homeolog Protein, matrix metallopeptidase 13 (collagenase 3) Protein, matrix metalloproteinase 13 Protein, matrix metallopeptidase 13 (collagenase 3) like L homeolog Protein, MMP13 Protein, Mmp13 Protein, mmp13a Protein, mmp13l.S Protein, mmp13 Protein, LOC100136348 Protein, mmp13l.L Protein

Hintergrund: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue rodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal bryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

Molekulargewicht: 46.5 kDa

UniProt: P33435