Sorting Nexin 3 Protein (SNX3) (AA 3-162) (GST tag)

Produktnummer ABIN4976145

Produktdetails

Target: Sorting Nexin 3 (SNX3)

Protein-Typ: Recombinant

Proteineigenschaft: AA 3-162

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Sorting Nexin 3 Protein ist gelabelt mit GST tag.

Applikation: SDS-PAGE (SDS)

Sequenz: ETVADTRRLI TKPQNLNDAY GPPSNFLEID VSNPQTVGVG RGRFTTYEIR VKTNLPIFKL KESTVRRRYS DFEWLRSELE RESKVVVPPL PGKAFLRQLP FRGDDGIFDD NFIEERKQGL EQFINKVAGH PLAQNERCLH MFLQDEIIDK SYTPSKIRHA

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: Sorting Nexin 3 (SNX3)

Andere Bezeichnung: SNX3 (SNX3 Produkte)

Synonyme: SNX3 Protein, sdp3 Protein, Grd19 Protein, snx3a Protein, wu:fb53a08 Protein, zgc:123189 Protein, MCOPS8 Protein, SDP3 Protein, sorting nexin 3 Protein, sorting nexin 3 L homeolog Protein, potential phosphoinositide-binding protein similar to S. cerevisiae GRD19 (YOR357C) late Golgi protein involved in retrieval of proteins from prevacuolar compartment; same as cosmid orf Ca41C10.03 Protein, SNX3 Protein, snx3.L Protein, snx3 Protein, GRD19 Protein, Snx3 Protein

Hintergrund: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) . Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome mbrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway . Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G . Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes . Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the tranferrin:transferrin receptor complex to recycling endosomes, the function may involve the CSC retromer subcomplex . In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs .

Molekulargewicht: 45.9 kDa

UniProt: O60493