CHMP5 Protein (AA 1-219, full length) (His-SUMO Tag)

Produktnummer ABIN4975685

Produktdetails

Target: CHMP5 (Charged Multivesicular Body Protein 5 (CHMP5))

Protein-Typ: Recombinant

Proteineigenschaft: full length, AA 1-219

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CHMP5 Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MNRLFGKAKP KAPPPSLTDC IGTVDSRAES IDKKISRLDA ELVKYKDQIK KMREGPAKNM VKQKALRVLK QKRMYEQQRD NLAQQSFNME QANYTIQSLK DTKTTVDAMK LGVKEMKKAY KQVKIDQIED LQDQLEDMME DANEIQEALS RSYGTPELDE DDLEAELDAL GDELLADEDS SYLDEAASAP AIPEGVPTDT KNKDGVLVDE FGLPQIPAS

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: CHMP5 (Charged Multivesicular Body Protein 5 (CHMP5))

Andere Bezeichnung: CHMP5 (CHMP5 Produkte)

Synonyme: SNF7DC2 Protein, cgi-34 Protein, hspc177 Protein, pnas-2 Protein, vps60 Protein, chmp5 Protein, zgc:64125 Protein, C9orf83 Protein, HSPC177 Protein, PNAS-2 Protein, Vps60 Protein, 2210412K09Rik Protein, AW545668 Protein, RGD1305968 Protein, charged multivesicular body protein 5 S homeolog Protein, charged multivesicular body protein 5b Protein, charged multivesicular body protein 5 Protein, charged multivesicular body protein 5 L homeolog Protein, chromatin modifying protein 5 Protein, chmp5.S Protein, chmp5b Protein, CHMP5 Protein, chmp5.L Protein, chmp5 Protein, Chmp5 Protein

Hintergrund: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting mbrane of the endosome and mostly are delivered to lysosomes enabling degradation of mbrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating mbrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent mbrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or mbrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Molekulargewicht: 40.6 kDa

UniProt: Q9NZZ3