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TIGIT Protein (AA 16-142) (Fc Tag)

TIGIT Spezies: Kaninchen Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Produktnummer ABIN4949203
  • Target Alle TIGIT Proteine anzeigen
    TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 16-142
    Spezies
    • 18
    • 14
    • 8
    • 6
    • 4
    • 1
    • 1
    Kaninchen
    Quelle
    • 31
    • 7
    • 5
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses TIGIT Protein ist gelabelt mit Fc Tag.
    Applikation
    Functional Studies (Func)
    Sequenz
    AA 16-142
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.4 kDa. As a result of glycosylation, the protein migrates as 45-50 kDa under reducing (R) condition, and 90-116 kDa under non-reducing (NR) condition (SDS-PAGE).
    Reinheit
    >95 % as determined by SDS-PAGE.
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
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    Discover our top product TIGIT Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
  • Target
    TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
    Andere Bezeichnung
    TIGIT (TIGIT Produkte)
    Synonyme
    VSIG9 Protein, VSTM3 Protein, WUCAM Protein, ENSMUSG00000071552 Protein, Vstm3 Protein, RGD1563191 Protein, T-cell immunoreceptor with Ig and ITIM domains Protein, T cell immunoreceptor with Ig and ITIM domains Protein, TIGIT Protein, Tigit Protein
    Hintergrund
    T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
    Molekulargewicht
    40.4 kDa
    UniProt
    G1SLC1
    Pathways
    Cancer Immune Checkpoints
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