Nicotinamide phosphoribosyltransferase (NAMPT) (Active) Protein

Details zu Produkt Nr. ABIN413884, Anbieter: Anmelden zum Anzeigen
Proteinname
  • PBEF1
  • pbef
  • pbef1
  • 1110035O14Rik
  • PBEF
  • VF
  • VISFATIN
  • AI314458
  • AI480535
  • NAmPRTase
  • Pbef
  • Pbef1
  • Visfatin
  • visfatin
  • nicotinamide phosphoribosyltransferase
  • Nicotinamide phosphoribosyltransferase
  • NAMPT
  • nampt
  • Smon_0680
  • Mrub_2845
  • Cseg_3704
  • BC1002_3997
  • Ftrac_2686
  • Varpa_5681
  • Celal_3900
  • Deima_0880
  • BC1001_3724
  • Celly_1696
  • Clole_1542
  • Psed_2146
  • Psed_2158
  • Tsp_05934
  • Nampt
Spezies
Human
30
12
8
1
1
Quelle
Escherichia coli (E. coli)
35
4
2
2
2
1
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Applikation
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Reinheit ≥95 % by SDS-PAGE
Endotoxin-Niveau <0.1 ng/μg
ProductDetails: Biological Activity Comment Mimics insulin effects in differentiating 3T3-L1 cells.
Hintergrund Visfatin exerts insulin-mimetic effects that are dose-dependent and quantitatively similar to those of insulin in stimulating muscle and adipocyte glucose transport, and in inhibiting hepatocyte glucose production. Intravenous injection of recombinant visfatin in mice decreased plasma glucose in a dose-dependent fashion. In keeping with its insulin-mimetic effects, visfatin was as effective as insulin in reducing hyperglycemia in insulin-deficient diabetic mice. Visfatin was also found to be bound to and activate insulin receptor, causing receptor phosphorylation and the activation of downstream signaling molecules. However, visfatin and insulin did not compete for binding to the insulin receptor, indicating that the two proteins were recognized by different regions of the receptor. Thus, visfatin might play a role in glucose homeostasis and dysregulation in biosynthesis or signal transduction, and might contribute to the pathogenesis of diabetes.

Alternative Names: PBEF, Pre-B cell colony-enhancing factor, Nicotinamide phosphoribosyltransferase NAmPRTase, Nampt, MGC117256, DKFZP666B131, 1110035O14Rik.
Molekulargewicht 55.0 kDa
Gen-ID 10135
UniProt P43490
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Reconstitute in PBS to the concentration of 0.1-1 mg/mL.
Buffer Lyophilized with no additives.
Handhabung Centrifuge the vial prior to opening.
Lagerung -20 °C
Haltbarkeit 12 months
Produkt verwendet in: Šenolt, Kuklová, Cerezo, Hulejová, Filková, Bošanská, Pecha, Pavelka, Haluzík, Vencovský: "Adipokine profile is modulated in subcutaneous adipose tissue by TNFα inhibitors in patients with rheumatoid arthritis." in: Annals of the rheumatic diseases, Vol. 70, Issue 11, pp. 2054-6, 2011 (PubMed).

Xia, Zhang, Boini, Thacker, Li: "Membrane raft-lysosome redox signalling platforms in coronary endothelial dysfunction induced by adipokine visfatin." in: Cardiovascular research, Vol. 89, Issue 2, pp. 401-9, 2011 (PubMed).

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