Oncostatin M (OSM) (Active) Protein

Details zu Produkt Nr. ABIN413690, Anbieter: Anmelden zum Anzeigen
Proteinname
  • OSM
  • OncoM
  • oncostatin M
  • oncostatin M-like
  • oncostatin-M-like
  • OSM
  • Osm
  • LOC100342491
  • LOC100152038
Spezies
Human
56
9
5
1
Quelle
Escherichia coli (E. coli)
49
6
3
3
1
1
1
1
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Applikation
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Reinheit ≥98 % by SDS-PAGE
≥98 % by HPLC
Sterilität Sterile filtered
Endotoxin-Niveau <0.1 ng/μg
ProductDetails: Biological Activity Comment The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <2 ng/ml, corresponding to a specific activity of >5 x 10⁵ units/mg.
Hintergrund Oncostatin M (OSM) is an important growth regulating cytokine that affects, variably, a number of tumor and normal cells. Oncostatin M exerts inhibitory effects on the growth of A375 melanoma and other cellos, but augments the growth of normal fibroblasts, AIDs-related Kaposi sarcoma cells, and certain other cells. Recombinant Human Oncostatin M is a 26 kDa protein containing 227 amino acid residues.

Alternative Names: OSM, MGC20461, Oncostatin M.
Molekulargewicht 26.0 kDa
Gen-ID 5008
UniProt P13725
Forschungsgebiet Immunology, Innate Immunity, Cytokines, Signaling, Receptors
Pathways JAK-STAT Signalweg, Negative Regulation of Hormone Secretion
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Reconstitute in H₂O to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.
Buffer Sterile filtered and lyophilized with no additives
Konservierungsmittel Without preservative
Handhabung Centrifuge the vial prior to opening.
Lagerung -20 °C
Haltbarkeit 12 months
Produkt verwendet in: Lieu, Brice, Wiltzer, Hirst, Jans, Blondel, Moseley: "The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling." in: Journal of virology, Vol. 87, Issue 14, pp. 8261-5, 2013 (PubMed).

Sen, Che, Rajamani, Zerboni, Sung, Ptacek, Arvin: "Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 2, pp. 600-5, 2012 (PubMed).

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