TDO2 Protein (His tag)
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- Target Alle TDO2 Proteine anzeigen
- TDO2 (Tryptophan 2,3-Dioxygenase (TDO2))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Moskito
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses TDO2 Protein ist gelabelt mit His tag.
- Applikation
- SDS-PAGE (SDS)
- Produktmerkmale
- Full-length TDO (Anopheles gambiae) is fused at the N-terminus to a His-tag.
- Reinheit
- >98 % (SDS-PAGE)
- Endotoxin-Niveau
- .
- Top Product
- Discover our top product TDO2 Protein
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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Specific activity towards L-Trp: 87.0μmol/hr per mg. TDO catalyzes the oxidative opening of the L-tryptophan indole moiety to yield N-formylkynurenine (NFK).
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. In 50 mM sodium phosphate pH 8.0, containing 0.15M sodium chloride, 0.2M imidazole and 10 % glycerol.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
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Short Term Storage: -20°C
Long Term Storage: -80°C
Stable for at least 6 months after receipt when stored at -80°C. - Haltbarkeit
- 6 months
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- Target
- TDO2 (Tryptophan 2,3-Dioxygenase (TDO2))
- Andere Bezeichnung
- TDO (TDO2 Produkte)
- Synonyme
- Tdo2 Protein, tdo2l Protein, fi30d08 Protein, zgc:63488 Protein, wu:fi30d08 Protein, TDO2 Protein, fb62b10 Protein, tdo2 Protein, wu:fb62b10 Protein, zgc:103693 Protein, DDBDRAFT_0190495 Protein, DDBDRAFT_0231363 Protein, DDB_0190495 Protein, DDB_0231363 Protein, TDO Protein, TO Protein, TPH2 Protein, TRPO Protein, AA407491 Protein, chky Protein, Tdo Protein, tryptophan 2,3-dioxygenase b Protein, tryptophan 2,3-dioxygenase Protein, tryptophan 2,3-dioxygenase a Protein, tryptophan 2,3-dioxygenase L homeolog Protein, tdo2b Protein, tdo2 Protein, TDO2 Protein, MADE_02822 Protein, CtCNB1_3657 Protein, tdo2a Protein, CNC04830 Protein, tdo Protein, Mrub_2119 Protein, Deipr_2235 Protein, Acav_1166 Protein, Mesop_4278 Protein, Tdo2 Protein, tdo2.L Protein
- Hintergrund
- Tryptophan 2,3-dioxygenase (TDO) is a heme-containing dioxygenase catalyzing the addition of molecular oxygen across the 2,3-double bond of the indole ring of tryptophan to form N-formylkynurenine (NFK). In Anopheles gambiae, TDO is the only enzyme able to catalyze the first and rate-limiting step in L-Trp catabolism through the kynurenine pathway. Tryptophan is an essential amino acid for protein synthesis and also the precursor for production of a number of neurotransmitters, such as serotonin and melatonin, in mosquitoes, the kynurenine pathway is essential for eye pigmentation. Conceivably, the tryptophan-using pathways should be regulated in a coordinated manner in mosquitoes as well as in other species and TDO activation/inactivation processes could play an essential role in these phenomena.
- Molekulargewicht
- ~47.9kDa
- UniProt
- O77457
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