GAD Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2721538

Produktdetails

Target: GAD (GAD1) (Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses GAD Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human GAD1 / GAD67 (transcript variant GAD67) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: GAD (GAD1) (Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))

Andere Bezeichnung: Gad1,gad67 (GAD1 Produkte)

Synonyme: CPSQ1 Protein, GAD Protein, SCP Protein, GAD-67 Protein, cpsq1 Protein, gad1 Protein, gad1-A Protein, gad67 Protein, GAD67 Protein, GAD1 Protein, GLUTAMATE DECARBOXYLASE Protein, GLUTAMATE DECARBOXYLASE 1 Protein, MKP11.30 Protein, MKP11_30 Protein, glutamate decarboxylase Protein, EP10 Protein, GAD25 Protein, GAD44 Protein, Gad-1 Protein, Gad67 Protein, glutamate decarboxylase 1 Protein, glutamate decarboxylase 1 L homeolog Protein, glutamate decarboxylase Protein, glutamate decarboxylase 1b Protein, GAD1 Protein, gad1.1.L Protein, GAD Protein, Gad1 Protein, gad1b Protein

Hintergrund: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Molekulargewicht: 66.7 kDa

NCBI Accession: NP_000808