CBFA2T2 Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2713251

Produktdetails

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 4

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CBFA2T2 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human CBFA2T2 (transcript variant 4) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Andere Bezeichnung: Cbfa2t2 (CBFA2T2 Produkte)

Synonyme: MTGR1 Protein, A430091M07 Protein, C330013D05Rik Protein, Cbfa2t2h Protein, EHT Protein, ZMYND3 Protein, p85 Protein, XETOR Protein, cbfa2t2-a Protein, CBFA2/RUNX1 translocation partner 2 Protein, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) Protein, CBFA2/RUNX1 translocation partner 2 L homeolog Protein, Cbfa2t2 Protein, CBFA2T2 Protein, cbfa2t2.L Protein

Hintergrund: In acute myeloid leukemia, especially in the M2 subtype, the t(821)(q22q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5&apos-region of the RUNX1 (AML1) gene fused to the 3&apos-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Molekulargewicht: 63.7 kDa

NCBI Accession: NP_001034798