Tumor Necrosis Factor (TNF) protein (Myc-DYKDDDDK Tag)

Details zu Produkt Nr. ABIN2712390, Anbieter: Anmelden zum Anzeigen
Proteinname
  • TNF
  • tnf
  • dif
  • tnfa
  • xtnf
  • TNF-a
  • tnfsf2
  • tnf-alpha
  • TNF-alpha
  • DIF
  • TNFA
  • TNFSF2
  • TNFalpha
  • Tnfa
  • Tnfsf1a
  • RATTNF
  • TNFa
  • cTNF
  • TNF-ALPHA
  • Cachectin
  • Tnf-alpha
  • tnfa-like
  • tumor necrosis factor (TNF superfamily, member 2)
  • tumor necrosis factor
  • tumour necrosis factor alpha-like
  • tumor necrosis factor alpha
  • lipopolysaccharide-induced TNF factor
  • tumor necrosis factor b (TNF superfamily, member 2)
  • TNF
  • tnf
  • tnf-alpha
  • LITAF
  • Tnf
  • tnfb
Spezies
Human
114
50
29
9
6
5
5
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Quelle
HEK-293 Cells
156
26
15
6
4
3
3
2
2
2
2
1
1
Protein-Typ
Recombinant
Aufreinigungstag / Konjugat
Dieses Tumor Necrosis Factor Protein ist gelabelt mit Myc-DYKDDDDK Tag.
Applikation
Antibody Production (AbP), Functional Studies (Func), Protein Interaction (PI), Standard (STD)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Spezifität Optimal preservation of protein structure, post-translational modifications and functions.
Produktmerkmale
  • Recombinant human Tumor necrosis factor (TNF-alpha) protein expressed in HEK293 cells.
  • Produced with end-sequenced ORF clone
Reinheit > 80 % as determined by SDS-PAGE and Coomassie blue staining
Hintergrund This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Molekulargewicht 25.5 kDa
NCBI Accession NP_000585
Forschungsgebiet Receptors, Immunology, Cytokines, Growth Factors, Inflammation, Cancer, Virology
Pathways NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus
Applikationshinweise Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays
Kommentare

The tag is located at the C-terminal.

Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration > 50 μg/mL
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Lagerung -80 °C
Informationen zur Lagerung Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
Bilder des Herstellers
Western Blotting (WB) image for Tumor Necrosis Factor (TNF) protein (Myc-DYKDDDDK Tag) (ABIN2712390) Validation with Western Blot
Produkt verwendet in: Adini, Adini, Bazinet, Watnick, Bielenberg, DAmato: "Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014 (PubMed).

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