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Osteoprotegerin Protein (His tag)

TNFRSF11B Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. WB, ELISA Active
Produktnummer ABIN2566819
  • Target Alle Osteoprotegerin (TNFRSF11B) Proteine anzeigen
    Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Spezies
    • 17
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    Human
    Quelle
    • 12
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses Osteoprotegerin Protein ist gelabelt mit His tag.
    Applikation
    Western Blotting (WB), ELISA
    Produktmerkmale

    Measured by its binding ability in a functional ELISA. Immobilized rh TNFRSF11B at 10 μg/mL (100 μL/well) can bind human TNFSF11 Fc Chimera with a linear ranger of 4-256 ng/mL.

    Reinheit
    >95 % as determined by SDS-PAGE.
    Top Product
    Discover our top product TNFRSF11B Protein
  • Applikationshinweise
    This recombinant protein can be used for WB, ELISA. For research use only.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Lagerung
    -80 °C,-20 °C
    Informationen zur Lagerung
    Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
  • Target
    Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))
    Andere Bezeichnung
    Osteoprotegerin (TNFRSF11B Produkte)
    Synonyme
    CD254 Protein, ODF Protein, OPGL Protein, OPTB2 Protein, RANKL Protein, TRANCE Protein, hRANKL2 Protein, sOdf Protein, OCIF Protein, OPG Protein, TR1 Protein, Opg Protein, ocif Protein, opg Protein, tr1 Protein, TNF superfamily member 11 Protein, TNF receptor superfamily member 11b Protein, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Protein, TNF receptor superfamily member 11B Protein, tumor necrosis factor receptor superfamily member 11b S homeolog Protein, tumor necrosis factor receptor superfamily, member 11b Protein, TNFSF11 Protein, TNFRSF11B Protein, Tnfrsf11b Protein, tnfrsf11b.S Protein
    Substanzklasse
    Chemical
    Hintergrund
    Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
    Molekulargewicht
    44.4 kDa
    Gen-ID
    4982
    NCBI Accession
    NP_002537
    UniProt
    O00300
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