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CSF3R Protein (His tag)

CSF3R Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. WB Active
Produktnummer ABIN2566610
  • Target Alle CSF3R Proteine anzeigen
    CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Spezies
    • 18
    • 5
    • 2
    Human
    Quelle
    • 9
    • 7
    • 6
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CSF3R Protein ist gelabelt mit His tag.
    Applikation
    Western Blotting (WB)
    Produktmerkmale

    Measured by its ability to inhibit the GCSF-induced proliferation of NFS-60 mouse myeloid cells. The ED50 for this effect is typically 0. 02-2 μg /mL in the presence of 0. 125 ng /mL of recombinant human GCSF.

    Fusion tag: C-His Tag

    Reinheit
    >95 % as determined by SDS-PAGE.
    Top Product
    Discover our top product CSF3R Protein
  • Applikationshinweise
    This recombinant protein can be used for WB. For research use only.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Lagerung
    -80 °C,-20 °C
    Informationen zur Lagerung
    Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
  • Target
    CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))
    Andere Bezeichnung
    GCSFR (CSF3R Produkte)
    Synonyme
    CD114 Protein, GCSFR Protein, Cd114 Protein, Csfgr Protein, G-CSF-R Protein, G-CSFR Protein, CSF3R Protein, gcsfr Protein, cd114 Protein, colony stimulating factor 3 receptor Protein, colony stimulating factor 3 receptor (granulocyte) Protein, colony stimulating factor 3 receptor L homeolog Protein, granulocyte colony-stimulating factor receptor Protein, CSF3R Protein, Csf3r Protein, csf3r Protein, csf3r.L Protein, LOC100433338 Protein
    Hintergrund
    Granulocyte Colony Stimulating Factor Receptor (G-CSFR) is also known as Cluster of Differentiation 114 (CD114), CSF3R and GCSF, is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF), a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage. G-CSFR belongs to a family of cytokine receptors known as the hematopoietin receptor family. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type I II (FNIII) domains in the extracellular region. G-CSFR is present mainly on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. G-CSFR mediates the specific effect of GCSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, Ras-Raf-MAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.
    Molekulargewicht
    69 kDa
    Gen-ID
    1441
    NCBI Accession
    NP_000751
    UniProt
    Q99062
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