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TIGIT Protein (AA 22-141) (Fc Tag)

TIGIT Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN6951013
  • Target Alle TIGIT Proteine anzeigen
    TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 22-141
    Spezies
    • 17
    • 14
    • 8
    • 6
    • 4
    • 2
    • 1
    Human
    Quelle
    • 31
    • 7
    • 5
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses TIGIT Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 22-141
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 39.7 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product TIGIT Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 100 mM Glycine, 25 mM Arginine, 10 mM NaCl, pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Target
    TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
    Andere Bezeichnung
    TIGIT (TIGIT Produkte)
    Synonyme
    VSIG9 Protein, VSTM3 Protein, WUCAM Protein, ENSMUSG00000071552 Protein, Vstm3 Protein, RGD1563191 Protein, T-cell immunoreceptor with Ig and ITIM domains Protein, T cell immunoreceptor with Ig and ITIM domains Protein, TIGIT Protein, Tigit Protein
    Hintergrund
    T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
    Molekulargewicht
    39.7 kDa
    NCBI Accession
    NP_776160
    Pathways
    Cancer Immune Checkpoints
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