Neuropilin 1 Protein (NRP1) (AA 22-644) (Fc Tag)

Produktnummer ABIN2181550

Produktdetails

Target: Neuropilin 1 (NRP1)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 22-644

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Neuropilin 1 Protein ist gelabelt mit Fc Tag.

Sequenz: AA 22-644

Produktmerkmale: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 96.5 kDa. The protein migrates as 120-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >90 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Referenzen

Kerros, Tripathi, Zha, Mehrens, Sergeeva, Philips, Qiao, Peters, Katayama, Sukhumalchandra, Ruisaard, Perakis, St John, Lu, Mittendorf, Clise-Dwyer, Herrmann, Alatrash, Toniatti, Hanash, Ma, Molldrem: "Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells." in: The Journal of biological chemistry, Vol. 292, Issue 24, pp. 10295-10305, (2017) (PubMed).

Antigendetails

Target: Neuropilin 1 (NRP1)

Andere Bezeichnung: Neuropilin-1 (NRP1 Produkte)

Synonyme: NRP1 Protein, cd304 Protein, neuropilin Protein, np-1 Protein, npn-1 Protein, nrp Protein, nrp-1 Protein, vegf165r Protein, BDCA4 Protein, CD304 Protein, NP1 Protein, NRP Protein, VEGF165R Protein, C530029I03 Protein, NP-1 Protein, NPN-1 Protein, Npn1 Protein, Nrp Protein, neuropilin 1 Protein, neuropilin 1 L homeolog Protein, NRP1 Protein, nrp1 Protein, Nrp1 Protein, nrp1.L Protein

Hintergrund: Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.

Molekulargewicht: 96.5 kDa

Pathways: Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals