NPC2 Protein (AA 20-151) (His tag)

Produktnummer ABIN2181547

Produktdetails

Target: NPC2 (Niemann-Pick Disease, Type C2 (NPC2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 20-151

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses NPC2 Protein ist gelabelt mit His tag.

Sequenz: AA 20-151

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.5 kDa. The protein migrates as 20-24 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Antigendetails

Target: NPC2 (Niemann-Pick Disease, Type C2 (NPC2))

Andere Bezeichnung: Niemann-Pick Type C2 (NPC2 Produkte)

Synonyme: 2700012J19Rik Protein, AA408070 Protein, AU045843 Protein, HE1 Protein, EDDM1 Protein, re1 Protein, CE1 Protein, EPI-1 Protein, cb292 Protein, sb:cb292 Protein, NPC intracellular cholesterol transporter 2 Protein, Niemann-Pick disease, type C2 Protein, Npc2 Protein, NPC2 Protein, npc2 Protein

Hintergrund: Niemann-Pick disease type C2 protein (NPC2) is also known as epididymal secretory protein E1 and human epididymis-specific protein 1 (HE1). NPC2 is a intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. Also,NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Furthermore,the secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.

Molekulargewicht: 16.5 kDa

Pathways: SARS-CoV-2 Protein Interaktom