CD44 Protein (CD44) (AA 21-220) (Fc Tag)

Produktnummer ABIN2180800

Produktdetails

Target: CD44

Protein-Typ: Recombinant

Proteineigenschaft: AA 21-220

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CD44 Protein ist gelabelt mit Fc Tag.

Sequenz: AA 21-220

Produktmerkmale: This protein carries a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 48.7 kDa. The predicted N-terminus is Gln 21. The reducing (R) protein migrates as 76 kDa in SDS-PAGE due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Referenzen

Bhattacharya, Svechkarev, Souchek, Hill, Taylor, Natarajan, Mohs: "Impact of structurally modifying hyaluronic acid on CD44 interaction." in: Journal of materials chemistry. B, Vol. 5, Issue 41, pp. 8183-8192, (2017) (PubMed).

Antigendetails

Target: CD44

Andere Bezeichnung: CD44 (CD44 Produkte)

Synonyme: CDW44 Protein, CSPG8 Protein, ECMR-III Protein, HCELL Protein, HUTCH-I Protein, IN Protein, LHR Protein, MC56 Protein, MDU2 Protein, MDU3 Protein, MIC4 Protein, Pgp1 Protein, AU023126 Protein, AW121933 Protein, AW146109 Protein, HERMES Protein, Ly-24 Protein, Pgp-1 Protein, CD44A Protein, METAA Protein, RHAMM Protein, XCD44 Protein, cd44 Protein, cdw44 Protein, cspg8 Protein, ecmr-iii Protein, hcell Protein, lhr Protein, mc56 Protein, mdu2 Protein, mdu3 Protein, mic4 Protein, mutch-i Protein, pgp1 Protein, CD44 molecule (Indian blood group) Protein, syndecan 4 Protein, CD44 antigen Protein, CD44 molecule (Indian blood group) S homeolog Protein, CD44 Protein, SDC4 Protein, Cd44 Protein, cd44.S Protein

Hintergrund: CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. CD44 is expressed in a large number of mammalian cell types. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms.

Molekulargewicht: 48.7 kDa

Pathways: Glycosaminoglycan Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling