Azurocidin Protein (AA 27-250) (His tag)

Produktnummer ABIN2180608

Produktdetails

Target: Azurocidin (AZU1) (Azurocidin 1 (AZU1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 27-250

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Azurocidin Protein ist gelabelt mit His tag.

Sequenz: AA 27-250

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25 kDa. The protein migrates as 32-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Referenzen

Mayer, Dinkic, Jesenofsky, Klauss, Schirmacher, Dapunt, Hackert, Uhle, Hänsch, Gaida: "Changes in the microarchitecture of the pancreatic cancer stroma are linked to neutrophil-dependent reprogramming of stellate cells and reflected by diffusion-weighted magnetic resonance imaging." in: Theranostics, Vol. 8, Issue 1, pp. 13-30, (2017) (PubMed).

Antigendetails

Target: Azurocidin (AZU1) (Azurocidin 1 (AZU1))

Andere Bezeichnung: Azurocidin (AZU1 Produkte)

Synonyme: AZAMP Protein, AZU Protein, CAP37 Protein, HBP Protein, HUMAZUR Protein, NAZC Protein, AZU1 Protein, Azurocidin Protein, pHBP Protein, azurocidin 1 Protein, azurocidin Protein, AZU1 Protein, CpipJ_CPIJ007384 Protein

Hintergrund: Azurocidin (AZU1) is also known as Heparin-binding protein (HBP), Cationic antimicrobial protein CAP37, is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. which belongs to the peptidase S1 family and elastase subfamily. AZU1 / HBP contains 1 peptidase S1 domain. AZU1 binds heparin. The cytotoxic action of AZU1 is limited to many species of Gram-negative bacteria, this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. AZU1 may play a role in mediating recruitment of monocytes in the second wave of inflammation.

Molekulargewicht: 25.0 kDa