Interleukin 6 (IL6) (AA 25-211) (Active) Protein

Details zu Produkt Nr. ABIN2007389, Anbieter: Anmelden zum Anzeigen
Proteinname
  • Il-6
  • ILg6
  • Ifnb2
  • BSF2
  • HGF
  • HSF
  • IFNB2
  • IL-6
  • CHIL-6
  • il6
  • interleukin 6
  • interleukin 6 (interferon, beta 2)
  • interleukin-6
  • Il6
  • IL6
  • LOC517016
  • il-6
Proteineigenschaft
AA 25-211
19
15
12
6
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Spezies
Maus
86
44
30
5
5
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Quelle
Escherichia coli (E. coli)
136
26
14
7
3
2
2
1
1
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Applikation
Functional Studies (Func), SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktmerkmale The recombinant mouse IL6 consists of 188 amino acids and predicts a molecular mass of 21.9 KDa. It migrates as an approximately 22 KDa band in SDS-PAGE under reducing conditions.

Protein Structure: A DNA sequence encoding the mouse IL6 (P08505) (Phe25-Thr211) was expressed and purified.
Predicted N-Term: Met
Reinheit > 95 % as determined by SDS-PAGE
ProductDetails: Biological Activity Comment 1. Measured by its ability to bind biotinylated rat IL6ST-mFch in a functional ELISA.
2. Measured by its ability to bind biotinylated mouse IL6ST-Fc2h in a functional ELISA.
3. Measured by its ability to bind biotinylated mouse IL6ST-His in a functional ELISA.
4. Measured by its ability to bind biotinylated human IL6RB-Fch in a functional ELISA.
5. Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 0.4-2 ng/ml.
Hintergrund Synonyms: Il-6
UniProt P08505
Forschungsgebiet Cancer, Cytokines, Angiogenesis, Innate Immunity
Pathways Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagie, Cell RedoxHomeostasis
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handhabung Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Lagerung -20 °C,-80 °C
Informationen zur Lagerung Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Haltbarkeit 12 months
Bilder des Herstellers
 image for Interleukin 6 (IL6) (AA 25-211) (Active) protein (ABIN2007389) Interleukin 6 (IL6) (AA 25-211) (Active) protein
Allgemeine Veröffentlichungen Chung, Seo, Hur, Kim, Kim, Jung, Kim, Park, Shin: "Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women." in: Journal of human genetics, Vol. 48, Issue 5, pp. 243-8, 2003 (PubMed).

Heinrich, Behrmann, Müller-Newen, Schaper, Graeve: "Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway." in: The Biochemical journal, Vol. 334 ( Pt 2), pp. 297-314, 1998 (PubMed).

Kishimoto, Akira, Narazaki, Taga: "Interleukin-6 family of cytokines and gp130." in: Blood, Vol. 86, Issue 4, pp. 1243-54, 1995 (PubMed).

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