EPH Receptor A2 (EPHA2) (AA 1-534) (Active) protein (His tag)

Details zu Produkt Nr. ABIN2006004, Anbieter: Anmelden zum Anzeigen
Proteinname
  • EPHA2
  • epha2
  • MGC89505
  • ARCC2
  • CTPA
  • CTPP1
  • CTRCT6
  • ECK
  • AW545284
  • Eck
  • Myk2
  • Sek-2
  • Sek2
  • EPH receptor A2
  • EphA2
  • epoxide hydrolase
  • Eph receptor A2
  • EPHA2
  • epha2
  • ephA2
  • Epha2
Proteineigenschaft
AA 1-534
3
2
1
1
1
1
1
1
1
1
1
1
1
Spezies
Human
12
4
Quelle
Human Cells
6
2
2
2
2
1
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Aufreinigungstag / Konjugat
Dieses EPH Receptor A2 Protein ist gelabelt mit His tag.
Applikation
Functional Studies (Func), SDS-PAGE (SDS)
Optionen
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Produktmerkmale The recombinant human EPHA2 consists of 522 amino acids and predicts a molecular mass of 57.6 KDa. It migrates as an approximately 65-75 KDa band in SDS-PAGE under reducing conditions.

Protein Structure: A DNA sequence encoding the human EPHA2 (P29317) (Met1-Asn534) was expressed with a polyhistidine tag at the C-terminus.
Predicted N-Term: Ala 24
Reinheit > 95 % as determined by SDS-PAGE
Endotoxin-Niveau < 1.0 EU per μg of the protein as determined by the LAL method
ProductDetails: Biological Activity Comment Measured by its binding ability in a functional ELISA.
Immobilized human EPHA2-His at 10 μg/ml (100 μl/well) can bind human EFNA1-Fch , The EC50 of human EFNA1-Fch is 0.1-0.2 μg/ml.
Hintergrund Synonyms: ARCC2,CTPA,CTPP1,CTRCT6,ECK
UniProt P29317
Forschungsgebiet Signaling
Pathways RTK Signalweg
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer Lyophilized from sterile 20 mM Tris, 150 mM NaCl, pH 7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handhabung Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Lagerung -20 °C,-80 °C
Informationen zur Lagerung Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Haltbarkeit 12 months
Bilder des Herstellers
 image for EPH Receptor A2 (EPHA2) (AA 1-534) (Active) protein (His tag) (ABIN2006004) EPH Receptor A2 (EPHA2) (AA 1-534) (Active) protein (His tag)
Allgemeine Veröffentlichungen Zhang, Njauw, Park, Naruse, Asano, Tsao: "EphA2 is an essential mediator of UV radiation-induced apoptosis." in: Cancer research, Vol. 68, Issue 6, pp. 1691-6, 2008

Zhang, Njauw, Park, Naruse, Asano, Tsao: "EphA2 is an essential mediator of UV radiation-induced apoptosis." in: Cancer research, Vol. 68, Issue 6, pp. 1691-6, 2008 (PubMed).

Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Nowakowski, Cronin, McRee, Knuth, Nelson, Pavletich, Rogers, Sang, Scheibe, Swanson, Thompson: "Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography." in: Structure (London, England : 1993), Vol. 10, Issue 12, pp. 1659-67, 2002

Nowakowski, Cronin, McRee, Knuth, Nelson, Pavletich, Rogers, Sang, Scheibe, Swanson, Thompson: "Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography." in: Structure (London, England : 1993), Vol. 10, Issue 12, pp. 1659-67, 2002 (PubMed).