Neuregulin 1 (NRG1) (Extracellular Domain), (AA 20-241) (Active) protein (Fc Tag,ECD)

Details zu Produkt Nr. ABIN2005741, Anbieter: Anmelden zum Anzeigen
Proteinname
  • 6030402G23Rik
  • ARIA
  • D230005F13Rik
  • GGF
  • GGFII
  • HRG
  • HRGalpha
  • Hgl
  • NDF
  • SMDF
  • GGF2
  • HGL
  • HRG1
  • HRGA
  • MST131
  • NRG-1
  • heregulin
  • nrg1-A
  • pro-neuregulin-1
  • NRG1
  • wu:fm70e01
  • DKFZp459A1838
  • neuregulin 1
  • neuregulin 1 L homeolog
  • Nrg1
  • NRG1
  • nrg1.L
  • nrg1
Proteineigenschaft
Extracellular Domain, AA 20-241
5
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Spezies
Human
37
8
5
3
1
Quelle
Human Cells
28
14
6
2
2
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Aufreinigungstag / Konjugat
Dieses Neuregulin 1 Protein ist gelabelt mit Fc Tag,ECD.
Applikation
Functional Studies (Func), SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktmerkmale The recombinant human NRG1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 463 amino acids and has a calculated molecular mass of 51 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh NRG1/Fc monomer is approximately 60 kDa.

Protein Structure: A DNA sequence encoding the human NRG1 isoform alpha (Q02297-1) extracellular domain (Ser 20-Lys 241) was fused with the Fc region of human IgG1 at the C-terminus.
Predicted N-Term: Ser 20
Reinheit > 87 % as determined by SDS-PAGE
Endotoxin-Niveau < 1.0 EU per μg of the protein as determined by the LAL method
ProductDetails: Biological Activity Comment 1. Measured by its ability to biotinylated Human ErbB4-Fc in functional Elisa.
2. Measured by its ability to biotinylated Rhesus ErbB3-His in functional Elisa.
3. Measured by its ability to biotinylated Rhesus ErbB3 in functional Elisa.
Hintergrund Synonyms: ARIA,GGF,GGF2,HGL,HRG,HRG1,HRGA,MST131,MSTP131,NDF,Neuregulin 1,NRG1-IT2,SMDF
Molekulargewicht 51 kDa, 60 kDa
Forschungsgebiet Neurology, Glia marker
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handhabung Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Lagerung -20 °C,-80 °C
Informationen zur Lagerung Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Haltbarkeit 12 months
Bilder des Herstellers
 image for Neuregulin 1 (NRG1) (Extracellular Domain), (AA 20-241) (Active) protein (Fc Tag,ECD) (ABIN2005741) Neuregulin 1 (NRG1) (Extracellular Domain), (AA 20-241) (Active) protein (Fc Tag,ECD)
Allgemeine Veröffentlichungen Holmes, Sliwkowski, Akita, Henzel, Lee, Park, Yansura, Abadi, Raab, Lewis: "Identification of heregulin, a specific activator of p185erbB2." in: Science (New York, N.Y.), Vol. 256, Issue 5060, pp. 1205-10, 1992 (PubMed).