Neuregulin 1 (NRG1) (N-Term), (AA 2-246) (Active) protein (Fc Tag,ECD)

Details zu Produkt Nr. ABIN2004418, Anbieter: Anmelden zum Anzeigen
Proteinname
  • 6030402G23Rik
  • ARIA
  • D230005F13Rik
  • GGF
  • GGFII
  • HRG
  • HRGalpha
  • Hgl
  • NDF
  • SMDF
  • GGF2
  • HGL
  • HRG1
  • HRGA
  • MST131
  • NRG-1
  • heregulin
  • nrg1-A
  • pro-neuregulin-1
  • NRG1
  • wu:fm70e01
  • DKFZp459A1838
  • neuregulin 1
  • neuregulin 1 L homeolog
  • Nrg1
  • NRG1
  • nrg1.L
  • nrg1
Proteineigenschaft
N-Term, AA 2-246
5
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Spezies
Human
37
8
5
3
1
Quelle
Human Cells
28
14
6
2
2
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Aufreinigungstag / Konjugat
Dieses Neuregulin 1 Protein ist gelabelt mit Fc Tag,ECD.
Applikation
Functional Studies (Func), SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktmerkmale The recombinant human NRG1(aa2-246)/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 505 amino acids and has a calculated molecular mass of 55.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 75 kDa due to glycosylation.

Protein Structure: A DNA sequence encoding the N-terminal fragment (Ser 2-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was fused with the Fc region of human IgG1 at the N-terminus.
Predicted N-Term: Glu
Reinheit > 85 % as determined by SDS-PAGE
Endotoxin-Niveau < 1.0 EU per μg of the protein as determined by the LAL method
Biological Activity Comment 1. Measured by its binding ability in a functional ELISA.
2. Immobilized human Erbb3-his at 10 μg/mL (100 μl/well) can bind human NRG1 (aa 2-246)-Fc, The EC50 of human NRG1 (aa 2-246)-Fc is 0.16 μg/mL.
3. Immobilized Rhesus Erbb3-his at 10 μg/mL (100 μl/well) can bind human NRG1 (aa 2-246)-Fc, The EC50 of human NRG1 (aa 2-246)-Fc is 0.37 μg/mL.
Hintergrund Synonyms: ARIA,GGF,GGF2,HGL,HRG,HRG1,HRGA,MST131,MSTP131,NDF,Neuregulin 1,NRG1-IT2,SMDF
Molekulargewicht 55.2 kDa, 75 kDa
Forschungsgebiet Neurology, Glia marker
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handhabung Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Lagerung -20 °C,-80 °C
Informationen zur Lagerung Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Haltbarkeit 12 months
Bilder des Herstellers
 image for Neuregulin 1 (NRG1) (N-Term), (AA 2-246) (Active) protein (Fc Tag,ECD) (ABIN2004418) Neuregulin 1 (NRG1) (N-Term), (AA 2-246) (Active) protein (Fc Tag,ECD)
Allgemeine Veröffentlichungen Holmes, Sliwkowski, Akita, Henzel, Lee, Park, Yansura, Abadi, Raab, Lewis: "Identification of heregulin, a specific activator of p185erbB2." in: Science (New York, N.Y.), Vol. 256, Issue 5060, pp. 1205-10, 1992 (PubMed).