Interleukin 13 (IL13) (AA 1-132) (Active) Protein

Details zu Produkt Nr. ABIN2003837, Anbieter: Anmelden zum Anzeigen
Proteinname
  • IL13
  • IL-13
  • P600
  • Il-13
  • L13
  • interleukin 13
  • IL13
  • Il13
Proteineigenschaft
AA 1-132
10
9
8
6
4
3
2
2
2
2
1
1
1
Spezies
Cynomolgus
58
40
18
2
2
1
1
1
1
1
1
1
Quelle
Human Cells
85
10
8
3
3
3
3
2
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Applikation
Functional Studies (Func), SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktmerkmale The recombinant Cynomolgus IL13 consists of 112 amino acids and has a calculated molecular mass of 12.3 kDa as estimated by SDS-PAGE under reducing conditions.

Protein Structure: A DNA sequence encoding the Cynomolgus (Macaca fascicularis) IL13 (ABG75889.1) (Met 1-Asn 132) precursor was expressed.
Predicted N-Term: Ser 21
Reinheit > 85 % as determined by SDS-PAGE
Endotoxin-Niveau < 1.0 EU per μg of the protein as determined by the LAL method
Biological Activity Comment Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
The ED50 for this effect is typically 2-8 ng/mL.
Molekulargewicht 12.3 kDa
Forschungsgebiet Cancer, Cytokines, Innate Immunity
Pathways JAK-STAT Signalweg, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handhabung Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Lagerung -20 °C,-80 °C
Informationen zur Lagerung Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Haltbarkeit 12 months
Bilder des Herstellers
 image for Interleukin 13 (IL13) (AA 1-132) (Active) protein (ABIN2003837) Interleukin 13 (IL13) (AA 1-132) (Active) protein
Allgemeine Veröffentlichungen Monticelli, Solymar, Rao: "Role of NFAT proteins in IL13 gene transcription in mast cells." in: The Journal of biological chemistry, Vol. 279, Issue 35, pp. 36210-8, 2004 (PubMed).

Solymar, Agarwal, Bassing, Alt, Rao: "A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells." in: Immunity, Vol. 17, Issue 1, pp. 41-50, 2002 (PubMed).

Skinnider, Kapp, Mak: "The role of interleukin 13 in classical Hodgkin lymphoma." in: Leukemia & lymphoma, Vol. 43, Issue 6, pp. 1203-10, 2002 (PubMed).

Sironi, Sciacca, Matteucci, Conni, Vecchi, Bernasconi, Minty, Caput, Ferrara, Colotta: "Regulation of endothelial and mesothelial cell function by interleukin-13: selective induction of vascular cell adhesion molecule-1 and amplification of interleukin-6 production." in: Blood, Vol. 84, Issue 6, pp. 1913-21, 1994 (PubMed).

Minty, Chalon, Derocq, Dumont, Guillemot, Kaghad, Labit, Leplatois, Liauzun, Miloux: "Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses." in: Nature, Vol. 362, Issue 6417, pp. 248-50, 1993 (PubMed).