C-Type Lectin Domain Family 1, Member B (CLEC1B) (AA 58-229), (Extracellular Domain) (Active) protein (His tag)

Details zu Produkt Nr. ABIN2003677, Anbieter: Anmelden zum Anzeigen
Proteinname
  • CLEC1B
  • RGD1563517
  • 1810061I13Rik
  • CLEC2
  • CLEC2B
  • PRO1384
  • QDED721
  • Clec-2
  • Clec2
  • C-type lectin domain family 1, member B
  • C-type lectin domain family 1, member b
  • CLEC1B
  • Clec1b
  • LOC100346882
Proteineigenschaft
AA 58-229, Extracellular Domain
2
2
2
2
2
1
1
1
Spezies
Human
5
5
Quelle
Human Cells
4
2
2
1
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Aufreinigungstag / Konjugat
His tag
Applikation
Functional Studies (Func), SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktmerkmale The recombinant human CLEC1B comprises 188 amino acids with a predicted molecular mass of 22.7 kDa. As a result of glycosylation, the apparent molecular mass of rh CLEC1B is approximately 35-38 kDa in SDS-PAGE under reducing conditions.

Protein Structure: A DNA sequence encoding the human CLEC1B (NP_057593.3) extracellular domain (Gln 58-Pro 229) with a N-terminal polyhistidine tag was expressed.
Predicted N-Term: His
Reinheit > 76 % as determined by SDS-PAGE
Endotoxin-Niveau < 1.0 EU per μg of the protein as determined by the LAL method
ProductDetails: Biological Activity Comment 1. Measured by its binding ability in a functional ELISA.
2. Immobilized human Podoplanin at 10 μg/mL (100 μl/well) can bind biotinylated human CLEC1B-His, The EC50 of biotinylated human CLEC1B-His is 0.71 μg/mL.
Hintergrund Synonyms: 1810061I13Rik,CLEC2,CLEC2B,PRO1384,QDED721
Molekulargewicht 22.7 kDa, 35-38 kDa
NCBI Accession NP_057593
Forschungsgebiet Immunology, CD Antigens
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handhabung Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Lagerung -20 °C,-80 °C
Informationen zur Lagerung Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Haltbarkeit 12 months
Bilder des Herstellers
 image for C-Type Lectin Domain Family 1, Member B (CLEC1B) (AA 58-229), (Extracellular Domain) (Active) protein (His tag) (ABIN2003677) C-Type Lectin Domain Family 1, Member B (CLEC1B) (AA 58-229), (Extracellular Domain) (Active) protein (His tag)
Allgemeine Veröffentlichungen Hughes, Navarro-Núñez, Finney, Mourão-Sá, Pollitt, Watson: "CLEC-2 is not required for platelet aggregation at arteriolar shear." in: Journal of thrombosis and haemostasis : JTH, Vol. 8, Issue 10, pp. 2328-32, 2010

Hughes, Navarro-Núñez, Finney, Mourão-Sá, Pollitt, Watson: "CLEC-2 is not required for platelet aggregation at arteriolar shear." in: Journal of thrombosis and haemostasis : JTH, Vol. 8, Issue 10, pp. 2328-32, 2010 (PubMed).

Christou, Pearce, Watson, Mistry, Pollitt, Fenton-May, Johnson, Jackson, Watson, OCallaghan: "Renal cells activate the platelet receptor CLEC-2 through podoplanin." in: The Biochemical journal, Vol. 411, Issue 1, pp. 133-40, 2008 (PubMed).

Suzuki-Inoue, Kato, Inoue, Kaneko, Mishima, Yatomi, Yamazaki, Narimatsu, Ozaki: "Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells." in: The Journal of biological chemistry, Vol. 282, Issue 36, pp. 25993-6001, 2007 (PubMed).

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