Sclerostin (SOST) (AA 24-213), (Mature) protein (His tag)

Details zu Produkt Nr. ABIN2003109, Anbieter: Anmelden zum Anzeigen
Proteinname
  • LOC100313724
  • CDD
  • VBCH
  • 5430411E23Rik
  • sclerostin
  • sclerostin-like
  • LOC100313724
  • SOST
  • Sost
  • LOC100513306
Proteineigenschaft
AA 24-213, Mature
6
1
1
1
1
1
1
Spezies
Human
10
3
2
1
1
Quelle
Human Cells
4
3
2
2
2
2
1
1
Protein-Typ
Recombinant
Aufreinigungstag / Konjugat
Dieses Sclerostin Protein ist gelabelt mit His tag.
Applikation
SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktmerkmale The recombinant human SOST is a monomeric protein consisting of 197 amino acids and predicts a molecular mass of 22.5 kDa. As a result of glycosylation, the apparent molecular mass of rhSOST is approximately 28 kDa in SDS-PAGE under reducing conditions..

Protein Structure: A DNA sequence encoding the mature form of human SOST (NP_079513.1) (Gln 24-Tyr 213) was fused with a polyhistidine tag at the N-terminus.
Predicted N-Term: N-His
Reinheit > 90 % as determined by SDS-PAGE
Endotoxin-Niveau < 1.0 EU per μg of the protein as determined by the LAL method
Hintergrund Synonyms: CDD,SOST1,VBCH
Molekulargewicht 22.5 kDa, 28 kDa
NCBI Accession NP_079513
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.2
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handhabung Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Lagerung -20 °C,-80 °C
Informationen zur Lagerung Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Haltbarkeit 12 months
Bilder des Herstellers
 image for Sclerostin (SOST) (AA 24-213), (Mature) protein (His tag) (ABIN2003109) Sclerostin (SOST) (AA 24-213), (Mature) protein (His tag)
Allgemeine Veröffentlichungen Semënov, Tamai, He: "SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor." in: The Journal of biological chemistry, Vol. 280, Issue 29, pp. 26770-5, 2005

Semënov, Tamai, He: "SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor." in: The Journal of biological chemistry, Vol. 280, Issue 29, pp. 26770-5, 2005 (PubMed).

Kusu, Laurikkala, Imanishi, Usui, Konishi, Miyake, Thesleff, Itoh: "Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 24113-7, 2003 (PubMed).

Balemans, Patel, Ebeling, Van Hul, Wuyts, Lacza, Dioszegi, Dikkers, Hildering, Willems, Verheij, Lindpaintner, Vickery, Foernzler, Van Hul: "Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease." in: Journal of medical genetics, Vol. 39, Issue 2, pp. 91-7, 2002 (PubMed).

Brunkow, Gardner, Van Ness, Paeper, Kovacevich, Proll, Skonier, Zhao, Sabo, Fu, Alisch, Gillett, Colbert, Tacconi, Galas, Hamersma, Beighton, Mulligan: "Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein." in: American journal of human genetics, Vol. 68, Issue 3, pp. 577-89, 2001 (PubMed).

Balemans, Ebeling, Patel, Van Hul, Olson, Dioszegi, Lacza, Wuyts, Van Den Ende, Willems, Paes-Alves, Hill, Bueno, Ramos, Tacconi, Dikkers, Stratakis, Lindpaintner, Vickery, Foernzler, Van Hul: "Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)." in: Human molecular genetics, Vol. 10, Issue 5, pp. 537-43, 2001 (PubMed).

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