Retinol Binding Protein 4, Plasma (RBP4) (AA 1-201), (Proform) (Active) protein (His tag)

Details zu Produkt Nr. ABIN2002658, Anbieter: Anmelden zum Anzeigen
Proteinname
  • rbp4
  • MGC54038
  • srbp
  • 2310002G05Rik
  • 2610028L19Rik
  • HSRBP4
  • RBP4
  • RBP
  • RNBP
  • RDCCAS
  • Rbp-4
  • RBPA
  • PRBP
  • retinol binding protein 4, plasma
  • polymerase (RNA) II (DNA directed) polypeptide D
  • renin binding protein
  • rbp4
  • Polr2d
  • RENBP
  • RBP4
  • Rbp4
Proteineigenschaft
AA 1-201, Proform
25
8
5
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Spezies
Human
38
11
8
5
3
2
2
2
1
1
1
1
1
Quelle
Human Cells
25
12
10
6
6
5
2
2
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Aufreinigungstag / Konjugat
Dieses RBP4 Protein ist gelabelt mit His tag.
Applikation
Functional Studies (Func), SDS-PAGE (SDS)
Optionen
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Produktmerkmale The recombinant human RBP4 consists of 194 amino acids after removal of the signal peptide and migrates as an approximately 23 kDa protein as predicted.

Protein Structure: A DNA sequence encoding the pro form of human RBP4 (NP_006735.2) (Met 1-Leu 201) was expressed with a C-terminal polyhistidine tag.
Predicted N-Term: Glu 19
Reinheit > 85 % as determined by SDS-PAGE
Endotoxin-Niveau < 1.0 EU per μg of the protein as determined by the LAL method
ProductDetails: Biological Activity Comment Measured by its ability to bind all-trans retinoic acid. The binding of retinoic acid results in the quenching of Trp fluorescence in RBP4.
The 50% binding concentration (BC50) is > 1.0 μM.
Hintergrund Synonyms: RDCCAS
Molekulargewicht 23 kDa
NCBI Accession NP_006735
Forschungsgebiet Cardiovascular, Atherosclerosis, Metabolism, Hormones, Cytokines
Pathways Regulatorische RNA Pathways, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.2
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handhabung Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Lagerung -20 °C,-80 °C
Informationen zur Lagerung Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Haltbarkeit 12 months
Bilder des Herstellers
 image for Retinol Binding Protein 4, Plasma (RBP4) (AA 1-201), (Proform) (Active) protein (His tag) (ABIN2002658) Retinol Binding Protein 4, Plasma (RBP4) (AA 1-201), (Proform) (Active) protein (His tag)
Produkt verwendet in: Li, Xia, Sheikh, Cheng, Li, Yang: "Involvement of RBP4 in hyperinsulinism-induced vascular smooth muscle cell proliferation." in: Endocrine, Vol. 48, Issue 2, pp. 472-82, 2015 (PubMed).

Wang, Chen, Liu, Zhou, Sun, Xia: "Retinol binding protein 4 induces mitochondrial dysfunction and vascular oxidative damage." in: Atherosclerosis, Vol. 240, Issue 2, pp. 335-44, 2015 (PubMed).

Li, Xia, Sheikh, Cheng, Li, Yang: "Retinol binding protein 4 promotes hyperinsulinism?induced proliferation of rat aortic smooth muscle cells." in: Molecular medicine reports, Vol. 9, Issue 5, pp. 1634-40, 2014 (PubMed).

Allgemeine Veröffentlichungen Balagopal, Graham, Kahn, Altomare, Funanage, George: "Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation." in: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 5, pp. 1971-4, 2007

Balagopal, Graham, Kahn, Altomare, Funanage, George: "Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation." in: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 5, pp. 1971-4, 2007 (PubMed).

Cho, Youn, Lee, Lee, Min, Kwak, Lee, Park: "Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes." in: Diabetes Care, Vol. 29, Issue 11, pp. 2457-61, 2006

Cho, Youn, Lee, Lee, Min, Kwak, Lee, Park: "Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes." in: Diabetes Care, Vol. 29, Issue 11, pp. 2457-61, 2006 (PubMed).

Zanotti, Berni: "Plasma retinol-binding protein: structure and interactions with retinol, retinoids, and transthyretin." in: Vitamins and hormones, Vol. 69, pp. 271-95, 2004

Zanotti, Berni: "Plasma retinol-binding protein: structure and interactions with retinol, retinoids, and transthyretin." in: Vitamins and hormones, Vol. 69, pp. 271-95, 2004 (PubMed).

Quadro, Blaner, Hamberger, Van Gelder, Vogel, Piantedosi, Gouras, Colantuoni, Gottesman: "Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice." in: The Journal of biological chemistry, Vol. 277, Issue 33, pp. 30191-7, 2002

Quadro, Blaner, Hamberger, Van Gelder, Vogel, Piantedosi, Gouras, Colantuoni, Gottesman: "Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice." in: The Journal of biological chemistry, Vol. 277, Issue 33, pp. 30191-7, 2002 (PubMed).

Colantuoni, Romano, Bensi, Santoro, Costanzo, Raugei, Cortese: "Cloning and sequencing of a full length cDNA coding for human retinol-binding protein." in: Nucleic acids research, Vol. 11, Issue 22, pp. 7769-76, 1984

Colantuoni, Romano, Bensi, Santoro, Costanzo, Raugei, Cortese: "Cloning and sequencing of a full length cDNA coding for human retinol-binding protein." in: Nucleic acids research, Vol. 11, Issue 22, pp. 7769-76, 1984 (PubMed).