Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2) (AA 18-144) (Active) Protein

Details zu Produkt Nr. ABIN2001920, Anbieter: Anmelden zum Anzeigen
Proteinname
  • CSF2
  • GM-CSF
  • GMCSF
  • CSF
  • Csfgm
  • Gm-CSf
  • MGI-IGM
  • Gm-csf
  • Gmcsf
  • granulocyte-macrophage colony-stimulating-factor
  • colony stimulating factor 2 (granulocyte-macrophage)
  • granulocyte-macrophage colony-stimulating factor
  • granulocyte-macrophage colony stimulating factor
  • GM-CSF
  • CSF2
  • Csf2
Proteineigenschaft
AA 18-144
23
6
4
3
2
2
1
1
1
1
1
1
1
1
1
Spezies
Human
57
22
12
4
3
2
2
1
1
1
1
1
1
Quelle
Hefe
54
8
8
5
4
3
2
2
2
2
1
1
1
1
1
1
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Applikation
Functional Studies (Func), SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktmerkmale The recombinant human GMCSF consists of 127 amino acids and predicts a molecular mass of 14.5 kDa. It migrates as an approximately 28-32 kDa band in SDS-PAGE under reducing conditions.

Protein Structure: A DNA sequence encoding human GMCSF (NP_000749.2) (Ala18-Glu144) was expressed.
Predicted N-Term: Ala 18
Reinheit > 95 % as determined by SDS-PAGE
ProductDetails: Biological Activity Comment Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
The ED50 for this effect is typically 0.1-0.6 ng/ml.
Hintergrund Synonyms: GM-CSF,GMCSF
Molekulargewicht 14.5 kDa, 28-32 kDa
NCBI Accession NP_000749
Pathways JAK-STAT Signalweg, Cellular Response to Molecule of Bacterial Origin
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handhabung Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Lagerung -20 °C,-80 °C
Informationen zur Lagerung Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Haltbarkeit 12 months
Bilder des Herstellers
SDS-PAGE (SDS) image for Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2) (AA 18-144) (Active) protein (ABIN2001920) Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2) (AA 18-144) (Active) protein
Allgemeine Veröffentlichungen Volmar, Ait-Ghezala, Frieling, Paris, Mullan: "The granulocyte macrophage colony stimulating factor (GM-CSF) regulates amyloid beta (Abeta) production." in: Cytokine, Vol. 42, Issue 3, pp. 336-44, 2008 (PubMed).

Kato, Noma, Kitagawa, Takahashi, Oshitani, Kitagawa: "Distinct role of c-Jun N-terminal kinase isoforms in human neutrophil apoptosis regulated by tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 28, Issue 4, pp. 235-43, 2008 (PubMed).

Ebner, Bandion, Binder, de Martin, Schmid: "GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta." in: Blood, Vol. 102, Issue 1, pp. 192-9, 2003 (PubMed).

Hamilton: "GM-CSF in inflammation and autoimmunity." in: Trends in immunology, Vol. 23, Issue 8, pp. 403-8, 2002 (PubMed).

Frolova, Dolganov, Mazo, Smirnov, Copeland, Stewart, OBrien, Dean: "Linkage mapping of the human CSF2 and IL3 genes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 11, pp. 4821-4, 1991 (PubMed).

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