Leukemia Inhibitory Factor (LIF) (Active) Protein

Details zu Produkt Nr. ABIN1841742, Anbieter: Anmelden zum Anzeigen
Proteinname
  • CDF
  • DIA
  • HILDA
  • MLPLI
  • A230075M04Rik
  • AW061234
  • LIF
  • leukemia inhibitory factor
  • LIF, interleukin 6 family cytokine
  • leukemia inhibitory factor receptor
  • Lif
  • LIF
  • Lifr
Spezies
Maus
49
37
6
1
1
Quelle
Escherichia coli (E. coli)
54
8
7
6
2
2
2
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Applikation
ELISA, In vitro Assay (in vitro), In vivo Studies (in vivo), Western Blotting (WB)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Sequenz MSPLPITPVN ATCAIRHPCH GNLMNQIKNQ LAQLNGSANA LFISYYTAQG EPFPNNVEKL CAPNMTDFPS FHGNGTEKTK LVELYRMVAY LSASLTNITR DQKVLNPTAV SLQVKLNATI DVMRGLLSNV LCRLCNKYRV GHVDVPPVPD HSDKEAFQRK KLGCQLLGTY KQVISVVVQA F
Kreuzreaktivität Human
Reinheit ≥ 95%
Sterilität Sterile filtered
Endotoxin-Niveau ≤ 1.00 LAL (EUs/ug)
Güteklasse Animal-Free
Biological Activity Comment
  • Bioactivity Assay: Induce IL-6 production from M1 cells
  • Bioactivity Acceptance Criteria ED50 (ng/ml): 1 ng/mL
  • Bioactivity Acceptance Criteria (Units/mg): 1 x 10^6 units/mg
Hintergrund Mouse leukemia inhibitory factor (LIF) is a member of the interleukin 6 (IL-6) family that is made by a variety of adult and embryonic tissues. LIF signals through the glycoprotein 130 (gp130)/LIF receptor (LIFR) heterodimer to activate STAT3 and MAPK signaling. LIF functions during hematopoietic differentiation, neuronal cell differentiation, kidney development, and inflammatory processes. The application of mouse LIF to long-term culture systems promotes mouse embryonic stem (ES) cell self-renewal and pluripotency, similar to the functional activity of bFGF (FGF2) in human ES cell culture systems.

Alternate Names: Leukocyte Inhibitory Factor
Molekulargewicht Monomer: 20.0 MW Monomer/Total (kDa)
UniProt P09056
Pathways JAK-STAT Signalweg, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Stem Cell Maintenance, Growth Factor Binding
Applikationshinweise Optimal working dilution should be determined by the investigator.
Kommentare

Media Components: Luria Broth

Animal Components: This product is produced with no animal derived raw products. All processing and handling employs animal free equipment and animal free protocols.

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Sterile 10 mM acetic acid at 0.1 mg/mL
Buffer Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing : 0.1 % Trifluoroacetic Acid (TFA)
Konservierungsmittel Without preservative
Handhabung Centrifuge vial before opening.
Lagerung 4 °C/-20 °C/-80 °C
Informationen zur Lagerung 12 months from date of receipt when stored at -20°C to-80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.
Haltbarkeit 12 months
Bilder des Herstellers
 image for Leukemia Inhibitory Factor (LIF) (Active) protein (ABIN1841742) Leukemia Inhibitory Factor (LIF) (Active) protein
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