SOD2 Protein (His tag)

Produktnummer ABIN1686712

Produktdetails

Target: SOD2 (Superoxide Dismutase 2, Mitochondrial (SOD2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses SOD2 Protein ist gelabelt mit His tag.

Applikation: Western Blotting (WB), SDS-PAGE (SDS)

Sequenz: MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN NLNVTEEKYQ EALAKGDVTA QIALQPALKF NGGGHINHSI FWTNLSPNGG GEPKGELLEA IKRDFGSFDK FKEKLTAASV GVQGSGWGWL GFNKERGHLQ IAACPNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY LKAIWNVINW ENVTERYMAC KK

Spezifität: ~25 kDa

Aufreinigung: Affinity Purified

Reinheit: >90%

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

This product has been certified >90% pure using SDS-PAGE analysis.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: Lot specific

Buffer: 50 mM Tris/HCl pH 7.7, 0.15M NaCl, 5 mM DTT, 10 % glycerol

Lagerung: -20 °C

Antigendetails

Target: SOD2 (Superoxide Dismutase 2, Mitochondrial (SOD2))

Andere Bezeichnung: Mn SOD (SOD2 Produkte)

Synonyme: LOC100101896 Protein, MNSOD Protein, GB14346 Protein, sod2 Protein, MGC88869 Protein, Sod2 Protein, CG8905 Protein, Dmel\\CG8905 Protein, Mito SOD Protein, Mn SOD Protein, Mn-SOD Protein, Mn-SOD2 Protein, MnSOD Protein, MnSODII Protein, Mn[2+]SOD Protein, SOD Protein, SOD-2 Protein, SOD2 Protein, Sod-2 Protein, dSOD2 Protein, mitSOD2 Protein, mnSOD Protein, IPOB Protein, MVCD6 Protein, cb463 Protein, wu:fj33b01 Protein, zgc:73051 Protein, MnSOD Protein, manganese superoxide dismutase Protein, superoxide dismutase 2, mitochondrial Protein, superoxide dismutase 2 Protein, Mn superoxide dismutase Protein, Superoxide dismutase 2 (Mn) Protein, superoxide dismutase 2 L homeolog Protein, BDBG_07234 Protein, LOC100101896 Protein, MNSOD Protein, Sod2 Protein, sod2 Protein, LbMnSOD4 Protein, SOD2 Protein, LOC100282741 Protein, SOD-2 Protein, sod2.L Protein

Hintergrund: Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2, 5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extracellular space(8). SOD3 can also be distinguished by its heparin-binding capacity (1).

Molekulargewicht: approx. 25 kDa

Gen-ID: 24787

UniProt: P04179

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis, Negative Regulation of intrinsic apoptotic Signaling