Nicotinamide phosphoribosyltransferase (NAMPT) (AA 1-491) protein (DYKDDDDK Tag)

Details zu Produkt Nr. ABIN1344283, Anbieter: Anmelden zum Anzeigen
Proteinname
  • PBEF1
  • pbef
  • pbef1
  • 1110035O14Rik
  • PBEF
  • VF
  • VISFATIN
  • AI314458
  • AI480535
  • NAmPRTase
  • Pbef
  • Pbef1
  • Visfatin
  • visfatin
  • nicotinamide phosphoribosyltransferase
  • Nicotinamide phosphoribosyltransferase
  • NAMPT
  • nampt
  • Smon_0680
  • Mrub_2845
  • Cseg_3704
  • BC1002_3997
  • Ftrac_2686
  • Varpa_5681
  • Celal_3900
  • Deima_0880
  • BC1001_3724
  • Celly_1696
  • Clole_1542
  • Psed_2146
  • Psed_2158
  • Tsp_05934
  • Nampt
Proteineigenschaft
AA 1-491
18
5
2
2
1
Spezies
Ratte (Rattus)
31
12
7
1
1
Quelle
HEK-293 Cells
36
3
2
2
2
1
1
Protein-Typ
Recombinant
Aufreinigungstag / Konjugat
Dieses NAMPT Protein ist gelabelt mit DYKDDDDK Tag.
Applikation
SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Kreuzreaktivität Ratte (Rattus)
Produktmerkmale Rat Nampt (visfatin/PBEF) (aa 1-491) is fused at the N-terminus to a FLAG®-tag.
Reinheit >90 % (SDS-PAGE)
Sterilität 0.2 μm filtered
Endotoxin-Niveau <0.1EU/μg purified protein (LAL test, Lonza).
Hintergrund Nicotinamide phosphoribosyltransferase (Nampt, pre-B cell colony-enhancing factor, PBEF, Visfatin) is an 52 kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
Molekulargewicht ~60kDa (SDS-PAGE)
UniProt Q80Z29
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.35 mg/mL
Buffer 0.2μm-filtered solution in PBS, pH 7.2.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.
Haltbarkeit 3 months
Produkt verwendet in: Spinnler, Gorski, Stolz, Schuster, Garten, Beck-Sickinger, Engelse, de Koning, Körner, Kiess, Maedler: "The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion." in: PLoS ONE, Vol. 8, Issue 1, pp. e54106, 2013 (PubMed).

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