APP Protein (His tag)
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- Target Alle APP Proteine anzeigen
- APP (Amyloid beta (A4) Precursor Protein (APP))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses APP Protein ist gelabelt mit His tag.
- Applikation
- SDS-PAGE (SDS)
- Aufreinigung
- purified by using conventional chromatography.
- Reinheit
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product APP Protein
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- Kommentare
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Synonyms: Amyloid beta A4 protein, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, CTFgamma
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1 M NaCl, 1 MM DTT
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Avoid repeated freezing and thawing cycles.
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- Target
- APP (Amyloid beta (A4) Precursor Protein (APP))
- Andere Bezeichnung
- APP (APP Produkte)
- Synonyme
- AAA Protein, ABETA Protein, ABPP Protein, AD1 Protein, APPI Protein, CTFgamma Protein, CVAP Protein, PN-II Protein, PN2 Protein, aaa Protein, abeta Protein, abpp Protein, ad1 Protein, appi Protein, ctfgamma Protein, cvap Protein, pn2 Protein, APP Protein, APP-like Protein, APPL Protein, Abeta Protein, BcDNA:GH04413 Protein, CG7727 Protein, Dmel\\CG7727 Protein, EG:65F1.5 Protein, appl Protein, Abpp Protein, Adap Protein, Ag Protein, Cvap Protein, E030013M08Rik Protein, betaApp Protein, app Protein, wu:fj34d10 Protein, wu:fk65e12 Protein, zgc:85740 Protein, amyloid beta precursor protein Protein, amyloid beta (A4) precursor protein Protein, beta amyloid protein precursor-like Protein, amyloid beta (A4) precursor protein a Protein, amyloid beta precursor protein L homeolog Protein, APP Protein, app Protein, Appl Protein, App Protein, appa Protein, app.L Protein
- Hintergrund
- APP, also known as amyloid beta A4 protein, functions as a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Recombinant human APP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
- Molekulargewicht
- 34.7 kDa (308aa) confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)
- NCBI Accession
- NP_000475
- Pathways
- Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
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